CDC42EP2 - CDC42 effector protein 2 Gene

Also Known as CEP2; BORG1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10435

Summary

CDC42, a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to, and negatively regulate the function of CDC42. Coexpression of this protein with CDC42 suggested a role of this protein in Actin filament assembly and cell shape control. [provided by RefSeq, Aug 2011]
Ubiquitous expression in fat (RPKM 13.9), gall bladder (RPKM 10.2) and 23 other tissues.

CDC42EP2 Products (1)

mRNA Protein Name
NM_006779.4 NP_006770.1 cdc42 effector protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTPase activator activity IMP
IMP: Inferred from mutant phenotype
10430899 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11584266 GOA
enables small GTPase binding IPI
IPI: Inferred from physical interaction
11035016 GOA
Biological Process GO Annotation Evidence References Source
involved in actin cytoskeleton organization IDA
IDA: Inferred from direct assay
10430899 GOA
involved in positive regulation of actin filament polymerization IDA
IDA: Inferred from direct assay
11035016 GOA
involved in positive regulation of pseudopodium assembly IDA
IDA: Inferred from direct assay
11035016 GOA
involved in regulation of cell shape IDA
IDA: Inferred from direct assay
11035016 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
11035016 GOA
located in membrane IDA
IDA: Inferred from direct assay
11035016 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
10430899 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDC42EP2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CDC42EP2 O14613 COX5B Homo sapiens P10606
Validated Y2H
32296183
Intra
CDC42EP2 O14613 NEDD9 Homo sapiens Q14511-2
Validated Y2H
32296183
Intra
CDC42EP2 O14613 CASS4 Homo sapiens Q9NQ75-2
Validated Y2H
32296183
Intra
CDC42EP2 O14613 ARHGAP26 Homo sapiens Q9UNA1
Y2H Prey Pooling
25416956
Intra
CDC42EP2 O14613 NME7 Homo sapiens Q9Y5B8
Validated Y2H
32296183
Intra
CDC42EP2 O14613 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra
CDC42EP2 O14613 CDC42 Homo sapiens P60953
Y2H
21988832
Intra
CDC42EP2 O14613 CDC42 Homo sapiens P60953
Validated Y2H
25416956
Intra
CDC42EP2 O14613 CDC42 Homo sapiens P60953
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02303 CDC42EP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02304 CDC42EP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02305 CDC42EP4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown