Rgma - repulsive guidance molecule family member A Gene

Also Known as C230063O06

Species: Mus musculus

Gene Type: protein coding
Gene ID: 244058

Summary

Enables coreceptor activity and signaling receptor binding activity. Acts upstream of or within several processes, including nervous system development; positive regulation of GTPase activity; and positive regulation of membrane protein ectodomain proteolysis. Located in cell surface. Is expressed in several structures, including future brain; gut; nervous system; sensory organ; and trunk somite. Human ortholog(s) of this gene implicated in multiple sclerosis. Orthologous to human RGMA (repulsive guidance molecule BMP co-receptor a). [provided by Alliance of Genome Resources, Apr 2022]

Rgma Products (1)

mRNA Protein Name
NM_177740.5 NP_808408.2 repulsive guidance molecule A precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables coreceptor activity IGI
IGI: Inferred from genetic interaction
15975920 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15975920 MGI
enables signaling receptor binding IPI
IPI: Inferred from physical interaction
26651291 MGI
Biological Process GO Annotation Evidence Références Source
acts upstream of or within BMP signaling pathway IGI
IGI: Inferred from genetic interaction
15975920 MGI
acts upstream of membrane protein ectodomain proteolysis IDA
IDA: Inferred from direct assay
26651291 MGI
acts upstream of or within negative regulation of neuron projection development IGI
IGI: Inferred from genetic interaction
26651291 MGI
acts upstream of or within negative regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
26651291 MGI
acts upstream of or within negative regulation of receptor binding IMP
IMP: Inferred from mutant phenotype
26651291 MGI
acts upstream of or within neural tube closure IMP
IMP: Inferred from mutant phenotype
14749425 MGI
acts upstream of or within neuron projection development IMP
IMP: Inferred from mutant phenotype
26651291 MGI
acts upstream of or within positive regulation of GTPase activity IDA
IDA: Inferred from direct assay
26651291 MGI
acts upstream of or within positive regulation of membrane protein ectodomain proteolysis IDA
IDA: Inferred from direct assay
26651291 MGI
acts upstream of or within regulation of BMP signaling pathway IDA
IDA: Inferred from direct assay
17472960 MGI
acts upstream of or within regulation of BMP signaling pathway IMP
IMP: Inferred from mutant phenotype
17472960 MGI
Cellular Component GO Annotation Evidence Références Source
located in cell surface IDA
IDA: Inferred from direct assay
14749425 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

repulsive guidance molecule A

  • RGM domain family, member A

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive MoleculesInhibitory Antibodies (2)
Cat. No. Nom du produit Effect
Pureté Phase
HY-P99359 Elezanumab Inhibitor 99.91% Phase 2
HY-P99959 Unasnemab 99.00% Phase 2

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS11894 RGMA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18785 Rgma Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25274 Rgma Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rgma NCBI NCBI:56963