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  3. RGMA - repulsive guidance molecule BMP co-receptor a Gene

RGMA - repulsive guidance molecule BMP co-receptor a Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as RGM

Gene ID: 56963 | Gene type: protein coding

About RGMA

Cytogenetic location: 15q26.1 Genomic coordinates (GRCh38): 15:93,035,271-93,089,211 (from NCBI)

This gene has 13 transcripts (splice variants), 203 orthologues and 2 paralogues. Biased expression in brain (RPKM 32.8), endometrium (RPKM 14.6) and 13 other tissues.

Summary

This gene encodes a member of the repulsive guidance molecule family. The encoded protein is a glycosylphosphatidylinositol-anchored glycoprotein that functions as an axon guidance protein in the developing and adult central nervous system. This protein may also function as a tumor suppressor in some cancers. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

RGMA Products(6)

mRNA Protein Name
NM_001166283.2 NP_001159755.1 repulsive guidance molecule A isoform 1
NM_001166286.2 NP_001159758.1 repulsive guidance molecule A isoform 2 precursor
NM_001166287.2 NP_001159759.1 repulsive guidance molecule A isoform 2 precursor
NM_001166288.2 NP_001159760.1 repulsive guidance molecule A isoform 2 precursor
NM_001166289.2 NP_001159761.1 repulsive guidance molecule A isoform 2 precursor
NM_020211.3 NP_064596.2 repulsive guidance molecule A isoform 3 precursor

RGMA Protein Structure

RGM_N

RGM_N: Repulsive guidance molecule (RGM) N-terminus (48 - 222)

RGM_C

RGM_C: Repulsive guidance molecule (RGM) C-terminus (226 - 412)

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  • 450 a.a.
Protein Preferred Names Protein Names

repulsive guidance molecule A

RGM domain family, member A

Recombinant RGMA Proteins

Cat. No. Product Name Accession Purity
HY-P71003 RGMA Protein, Human (His) AAI51133.1 (P169-G422) ≥95%
HY-P76572 RGMA Protein, Human (HEK293, His) Q96B86 (M1-G422) ≥95%
HY-P78197 RGMA Protein, Human (Biotinylated, HEK293, His-Avi) Q96B86 (C48-G422) ≥95%
HY-P78508 RGMA Protein, Human (HEK293, His-Avi) Q96B86 (C48-G422) ≥95%

Related Diseases

Diseases Alias
Hemochromatosis Type 2

Juvenile Hemochromatosis

Juvenile Hereditary Hemochromatosis

Hfe2

Jhh

Hemochromatosis Juvenile

Iron Overload Disease Juvenile

Hemochromatosis, Juvenile

Hemochromatosis, Type 2

Hemochromatosis

Hemochromatosis, Type 1
Intracranial Hypertension

Raised Intracranial Pressure
Amusia

Receptive Amusia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99359 Elezanumab Inhibitor 99.69% Phase 2
Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11894 RGMA Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus RGMA RGD RGD:1311983
Bos taurus RGMA VGNC VGNC:33906
Felis catus RGMA VGNC VGNC:64592
Macaca mulatta RGMA VGNC VGNC:76870
Mus musculus RGMA MGD MGI:2679262
Canis familiaris RGMA VGNC VGNC:45515
Others RGMA NCBI