RGMA Protein, Human (HEK293, His-Avi)

RGMA Protein, a repulsive guidance molecule (RGM) family member, plays diverse roles in nervous system development and function. It governs neural tube closure, restrains neurite outgrowth, inhibits neuron branching, and modulates mature synapse formation. Binding to NEO1/neogenin activates the RHOA-ROCK1 pathway, collapsing neuronal growth cones and inhibiting neurite outgrowth. RGMA's interaction with NEO1/neogenin also influences the HRAS-PTK2/FAK1-AKT1 pathway, leading to HRAS inactivation. As a BMP coreceptor, RGMA may signal through SMAD1, SMAD5, and SMAD8, emphasizing its significance in orchestrating essential molecular events in the nervous system. RGMA Protein, Human (HEK293, His-Avi) is the recombinant human-derived RGMA protein, expressed by HEK293, with C-Avi, C-His labeled tag. The total length of RGMA Protein, Human (HEK293, His-Avi) is 375 a.a., with molecular weight of 45-48 kDa.

RGMA Protein, a member of the repulsive guidance molecule (RGM) family, plays diverse roles in both the developing and adult nervous system. It governs cephalic neural tube closure, restrains neurite outgrowth, inhibits cortical neuron branching, and modulates the formation of mature synapses. Upon binding to its receptor NEO1/neogenin, RGMA triggers the activation of the RHOA-ROCK1/Rho-kinase signaling pathway through the UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, resulting in the collapse of the neuronal growth cone and inhibition of neurite outgrowth. Additionally, RGMA's interaction with NEO1/neogenin influences the HRAS-PTK2/FAK1-AKT1 pathway, leading to HRAS inactivation. Acting as a bone morphogenetic protein (BMP) coreceptor, RGMA may signal through SMAD1, SMAD5, and SMAD8. Its intricate network of interactions, including those with NEO1, BMP2, and BMP4, underscores RGMA's significance in orchestrating key molecular events essential for nervous system development and function.

Human

HEK293

C-Avi;C-His

Q96B86 (C48-G422)

56963  [NCBI]

45-48 kDa

Greater than 95% as determined by Tris-Bis PAGE.

<1 EU/μg, determined by LAL method.