GFRA2 - GDNF family receptor alpha 2 Gene

Also Known as NTNRA; RETL2; TRNR2; GDNFRB; NRTNR-ALPHA

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2675

About GFRA2

Cytogenetic location: 8p21.3 Genomic coordinates (GRCh38): 8:21,690,398-21,812,345 (from NCBI)

This gene has 8 transcripts (splice variants), 278 orthologues and 4 paralogues. Broad expression in spleen (RPKM 6.1), thyroid (RPKM 5.3) and 19 other tissues.

Summary

Glial cell line-derived neurotrophic factor (GDNF) and Neurturin (NTN) are two structurally related, potent Neurotrophic Factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF Receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its Other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

GFRA2 Products (3)

mRNA Protein Name
NM_001165038.2 NP_001158510.1 GDNF family receptor alpha-2 isoform b precursor
NM_001165039.2 NP_001158511.1 GDNF family receptor alpha-2 isoform c precursor
NM_001495.5 NP_001486.4 GDNF family receptor alpha-2 isoform a preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables glial cell-derived neurotrophic factor receptor activity IDA
IDA: Inferred from direct assay
29414779 GOA
enables heparan sulfate binding IDA
IDA: Inferred from direct assay
29414779 GOA
Biological Process GO Annotation Evidence Références Source
involved in glial cell-derived neurotrophic factor receptor signaling pathway IDA
IDA: Inferred from direct assay
29414779 GOA
Cellular Component GO Annotation Evidence Références Source
is active in plasma membrane IDA
IDA: Inferred from direct assay
9576965 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GFRA2 Protein Structure

GDNF

GDNF: GDNF/GAS1 domain (40 - 113)

GDNF

GDNF: GDNF/GAS1 domain (161 - 241)

GDNF

GDNF: GDNF/GAS1 domain (251 - 347)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 464 a.a.
Protein Preferred Names Protein Names

GDNF family receptor alpha-2

  • GDNF receptor beta

Recombinant GFRA2 Proteins

Cat. No. Nom du produit Accession Pureté
HY-P70192 GFRA2/GDNFR-alpha-2 Protein, Human (HEK293, His) O00451-1 (S22-S441) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Bladder Leiomyoma

  • Leiomyoma Of The Urinary Bladder
Retinal Degeneration

  • Degeneration Of Retina
Malignant Granular Cell Myoblastoma

  • Malignant Granular Cell Tumor

  • Granular Cell Tumor, Malignant

  • Malignant Granular Cell Neoplasm
Bladder Benign Neoplasm
Hirschsprung Disease 1

  • Hirschsprung Disease

  • Aganglionic Megacolon

  • Hscr

  • Hirschsprung'S Disease

  • Congenital Megacolon

  • Congenital Intestinal Aganglionosis

  • Colonic Aganglionosis

  • Hirschsprung Disease, Susceptibility To, 1

  • Hirschsprung Disease, Protection Against

  • HSCR1

  • Mgc

  • Pelvirectal Achalasia

  • Total Intestinal Aganglionosis

  • Megacolon, Aganglionic

  • Macrocolon

  • Hscr 1

  • Hirschsprung Disease Type 1

  • Hirschsprung Disease, Type 1

  • Congenital Dilatation Of Colon

  • Aganglionosis

  • Congenital Aganglionic Megacolon

  • Aganglionosis Of Colon

  • Bowel Aganglionosis

  • Colon Aganglionosis

  • Hirschsprung Megacolon
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS27452 Gfra2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05387 GFRA2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20935 Gfra2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus GFRA2 MGD MGI:1195462
Canis familiaris GFRA2 VGNC VGNC:41190
Bos taurus GFRA2 VGNC VGNC:29333
Felis catus GFRA2 VGNC VGNC:62530
Macaca mulatta GFRA2 VGNC VGNC:72918
Rattus norvegicus GFRA2 RGD RGD:61809
Others GFRA2 NCBI