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VILL - villin like Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 50853

About VILL

Cytogenetic location: 3p22.2 Genomic coordinates (GRCh38): 3:37,987,978-38,007,185 (from NCBI)

This gene has 10 transcripts (splice variants), 196 orthologues and 7 paralogues. Broad expression in stomach (RPKM 21.1), small intestine (RPKM 13.2) and 17 other tissues.

Summary

The protein encoded by this gene belongs to the villin/gelsolin family. It contains 6 gelsolin-like repeats and a headpiece domain. It may play a role in actin-bundling. [provided by RefSeq, Jul 2008]

VILL Products (5)

mRNA	Protein	Name
NM_001370264.1	NP_001357193.1	villin-like protein isoform 2
NM_001370265.1	NP_001357194.1	villin-like protein isoform 3
NM_001385038.1	NP_001371967.1	villin-like protein isoform 1
NM_001385039.1	NP_001371968.1	villin-like protein isoform 1
NM_015873.4	NP_056957.3	villin-like protein isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Références	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VILL Protein Structure

Gelsolin

VHP

0
200
400
600
800
856 a.a.

Protein Preferred Names	Protein Names
villin-like protein

Related Diseases

Diseases	Alias
Hyperekplexia	Hereditary Hyperekplexia Kok Disease Congenital Stiff Man Syndrome Familial Startle Disease Sthe Stiff-Baby Syndrome Hereditary Hyperexplexia Startle Disease Exaggerated Startle Reaction Hyperexplexia Hereditary Startle Disease, Familial Startle Reaction, Exaggerated Stiff-Man Syndrome, Congenital Stiff-Person Syndrome, Congenital Congenital Stiff-Man Syndrome Congenital Stiff-Person Syndrome Familial Hyperekplexia Startle Syndrome Stiff Baby Syndrome Hyperekplexia, Hereditary Stiff-Person Syndrome
Amyloidosis, Finnish Type	Finnish Type Amyloidosis Meretoja Syndrome Amyloidosis V Amyloidosis, Meretoja Type Amyloid Cranial Neuropathy With Lattice Corneal Dystrophy Lattice Corneal Dystrophy Type Ii Familial Amyloidosis, Finnish Type Familial Amyloid Polyneuropathy Type Iv Amyloidosis Due To Mutant Gelsolin Agel Amyloidosis Gelsolin Amyloidosis Hereditary Gelsolin Amyloidosis Lattice Corneal Dystrophy Type Ii Finnish Gelsolin-Related Amyloidosis Kymenlaakso Syndrome Lattice Corneal Dystrophy, Gelsolin Type Hereditary Amyloidosis, Finnish Type Lattice Corneal Dystrophy Type 2 Amyloidosis 5 AMYL5 Agel Familial Amyloidosis Finnish Type Meretoja Type Amyloidosis Type Iv Familial Amyloid Polyneuropathy Familial Amyloid Polyneuropathy, Type V Familial Amyloid Polyneuropathy, Type Iv

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS15651	VILL Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21456	Vill Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27974	Vill Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	VILL	VGNC	VGNC:36795
Felis catus	VILL	VGNC	VGNC:102865
Canis familiaris	VILL	VGNC	VGNC:48262
Mus musculus	VILL	MGD	MGI:1201781
Rattus norvegicus	VILL	RGD	RGD:1304843
Macaca mulatta	VILL	VGNC	VGNC:79897
Others	VILL	NCBI