Rivaroxaban-d4
Based on 1 publication(s) in Google Scholar
Rivaroxaban-d4 (BAY 59-7939-d4) is a deuterium labeled Rivaroxaban. Rivaroxaban is a highly potent，selective and direct Factor Xa (FXa) inhibitor, achieving a strong gain in anti-FXa potency (IC50 0.7 nM; Ki 0.4 nM).
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- Pureté: 98.73%
- CAS No.: 1132681-38-9
- Formule: C19H14D4ClN3O5S
- Masse moléculaire:439.91
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Rivaroxaban-d4
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Activité biologique
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1132681-38-9
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Unlabeled Cas 366789-02-8
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Appearance Solid
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Masse moléculaire 439.91
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Formule C19H14D4ClN3O5S
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Color White to off-white
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SMILES
O=C(C1=CC=C(Cl)S1)NC[C@H]2CN(C3=C([2H])C([2H])=C(N4C(COCC4)=O)C([2H])=C3[2H])C(O2)=O
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Synonyms
BAY 59-7939-d4
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
Solvant et solubilité
DMSO : 50 mg/mL (113.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (274 KB)
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SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Roehrig S, et al. Discovery of the novel antithrombotic agent 5-chloro-N-({(5S)-2-oxo-3- [4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene- 2-carboxamide (BAY 59-7939): an oral, direct factor Xa inhibitor. J Med Chem. 2005 Sep 22;48(19) [Content Brief]
[2]. Perzborn E, et al. In vitro and in vivo studies of the novel antithrombotic agent BAY 59-7939--an oral, direct Factor Xa inhibitor. J Thromb Haemost. 2005 Mar;3(3):514-21. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2732 mL | 11.3660 mL | 22.7319 mL | 56.8298 mL |
| 5 mM | 0.4546 mL | 2.2732 mL | 4.5464 mL | 11.3660 mL | |
| 10 mM | 0.2273 mL | 1.1366 mL | 2.2732 mL | 5.6830 mL | |
| 15 mM | 0.1515 mL | 0.7577 mL | 1.5155 mL | 3.7887 mL | |
| 20 mM | 0.1137 mL | 0.5683 mL | 1.1366 mL | 2.8415 mL | |
| 25 mM | 0.0909 mL | 0.4546 mL | 0.9093 mL | 2.2732 mL | |
| 30 mM | 0.0758 mL | 0.3789 mL | 0.7577 mL | 1.8943 mL | |
| 40 mM | 0.0568 mL | 0.2841 mL | 0.5683 mL | 1.4207 mL | |
| 50 mM | 0.0455 mL | 0.2273 mL | 0.4546 mL | 1.1366 mL | |
| 60 mM | 0.0379 mL | 0.1894 mL | 0.3789 mL | 0.9472 mL | |
| 80 mM | 0.0284 mL | 0.1421 mL | 0.2841 mL | 0.7104 mL | |
| 100 mM | 0.0227 mL | 0.1137 mL | 0.2273 mL | 0.5683 mL |
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