STING agonist-48
STING agonist-48 is a potent STING agonist that exhibits STING-dependent activity in vitro (EC50 = 4.02 μM). STING agonist-48 prefers to bind with the transmembrane domain (TMD) over the cytosolic cyclic dinucleotide (CDN) domain. STING agonist-48 shows adjuvant efficacy, enhancing IgG and Th1/Th2 cytokine responses in humanized STING mice. STING agonist-48 can be used for the study of inflammation-related diseases.
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- CAS No.: 3027712-31-5
- Formule: C23H16F4N2O3S
- Masse moléculaire:476.44
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
STING agonist-48 (Compound 7k) (6.25-50 μM, 24 h) induces a dose-dependent increase in luciferase activity in THF-ISRE IRF3 cells, demonstrating a strong STING activation effect, but it does not induce luciferase activity in THF-ISRE STING-/- cells, where activity was completely lost, and it maintains a dose-dependent increase in THF-ISRE TRIF/MAVS-/- cells[1].
STING agonist-48 does not cause any change in the thermal stability of the STING cytoplasmic domain[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male and female C57BL/6 humanized STING (huSTING; 6-12 weeks) mice were intramuscularly immunized and boosted (at a two-week interval) with 50 μL of either detergent-split A/Victoria/210/2009 (H3N2, A/Vic)[1].
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Dosage:20 μg
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Administration:I.m., 0 day, 14 days
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Result:Serum IgG1, IgG2, and total IgG titers were significantly increased in mice.
Increased secretion of IFN-γ, IL-4, and IL-5 from spleen cells.
Chemical Information
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CAS No. 3027712-31-5
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Masse moléculaire 476.44
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Formule C23H16F4N2O3S
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SMILES
O=C(C1=CC=C(N2CC3=C(O)C=CC=C3F)C(SCC2=O)=C1)NCC4=C(F)C=C(F)C=C4F
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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