GPR10 agonist 1
GPR10 agonist 1 (compound 18-S4) is a potent GPR10 agonist with EC50 values of 80, 7.8 nM in the presence (10%) or absence (0%) of FBS, respectively. GPR10 agonist 1 has the potential for the research of chronic obesity.
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- Formel: C200H324N58O57S2
- Molecular Weight:4517.20
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
Pharmacokinetic Parameters (1 mg/kg; s.c.; 7-9 weeks, male C57 mice)[1].
| t1/2(h) | Cmax(ng/mL) | AUClast(ng·h/mL) | AUC∞(ng·h/mL) | AUC0-24 h(ng·h/mL) |
| 7.81 | 1670 | 17700 | 17900 | 15500 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:24 weeks male mice (a diet-induced obesity (DIO) mouse model)[1]
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Dosage:0.5, 5 mg/kg
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Administration:S.c.; daily for 12 daily
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Result:Significantly decreased the body weight at 0.5 mg/kg and 5 mg/kg daily injection gave similar efficacy to the 0.5 mg/kg dose.
Ser-Arg-Ala-His-Gln-Cys-Ser-{Nle}-Glu-Thr-Arg-Thr-Cys-Asp-Ile-Asn-Pro-Ala-Trp-Tyr-Thr-Gly-{hArg}-Gly-Ile-Arg-Pro-Val-Gly-Arg-Phe-NH2 (Disulfide bridge: Cys6-Cys13; multiple ethylene glycol-fatty acid; hArg=Homoarginine)
SRAHQCS-{Nle}-ETRTCDINPAWYTG-{hArg}-GIRPVGRF-NH2 (Disulfide bridge: Cys6-Cys13; multiple ethylene glycol-fatty acid; hArg=Homoarginine)
Chemical Information
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Molecular Weight 4517.20
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Formel C200H324N58O57S2
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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