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Cat. No.: HY-151354

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Antibacterial agent 121

Antibacterial agent 121 (Compound 10) is an antibacterial agent. Antibacterial agent 121 shows anti-mycobacterial and anti-inflammatory activities and can be used in Tuberculosis (TB) research.

For research use only. We do not sell to patients.

CAS No.: 474099-18-8
Formula: C₁₈H₂₂N₂O₃S
Molecular Weight:346.44

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Antibacterial agent 121 Chemical Structure

CAS No.: 474099-18-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Antibacterial agent 121 (Compound 10) is an antibacterial agent. Antibacterial agent 121 shows anti-mycobacterial and anti-inflammatory activities and can be used in Tuberculosis (TB) research^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
RAW264.7	IC₅₀	15.3 μM Compound: 10	Anti-inflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as reduction in TNFalpha protein expression level after 24 hrs by ELISA Anti-inflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as reduction in TNFalpha protein expression level after 24 hrs by ELISA	[PMID: 34890996]
RAW264.7	IC₅₀	4.1 μM Compound: 10	Inhibition of NO production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent based analysis Inhibition of NO production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent based analysis	[PMID: 34890996]
RAW264.7	IC₅₀	80.2 μM Compound: 10	Anti-inflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as reduction in IL1beta protein expression level after 24 hrs by ELISA Anti-inflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as reduction in IL1beta protein expression level after 24 hrs by ELISA	[PMID: 34890996]
RAW264.7	CC₅₀	≥200 μM Compound: 10	Cytotoxicity against LPS-stimulated mouse RAW264.7 cells after 24 hrs by MTT assay Cytotoxicity against LPS-stimulated mouse RAW264.7 cells after 24 hrs by MTT assay	[PMID: 34890996]

In Vitro

Antibacterial agent 121 (0.2-200 µM; 24 h) inhibits M. tuberculosis H37Rv growth in bacterial culture^[1].
Antibacterial agent 121 (0-200 µM; 24 h) inhibits NO production in LPS-stimulated RAW 264.7 cell cultures with an IC₅₀ value of 4.1 µM^[1].
Antibacterial agent 121 (6.25-200 µM, 24 h) inhibits TNF-α and IL-1β production in LPS-stimulated macrophages^[1].
Antibacterial agent 121 (25-100 µM, 4 d) inhibits M. tuberculosis M299 with an MIC₅₀ value of 24.8 µM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

M. tuberculosis H37Rv
Concentration:

0.2-200 µM
Incubation Time:

24 hours
Result:

Inhibited Mtb H37Rv growth with MIC₅₀ of 8.6 µM.

Cell Viability Assay^[1]

Cell Line:

RAW 264.7 macrophages and J774A.1 macrophages
Concentration:

6.25-200 µM
Incubation Time:

24 hours
Result:

Showed IC₅₀ values of 15.3 µM and 28.4 µM for TNF-α and IL-1β production, respectively.

Chemical Information

CAS No. 474099-18-8
Molecular Weight 346.44
Formula C₁₈H₂₂N₂O₃S
SMILES

S=C(NC1=CC(OC)=C(OC)C(OC)=C1)NCCC2=CC=CC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Sanderson Dias Calixto, et al. Antimycobacterial and anti-inflammatory activities of thiourea derivatives focusing on treatment approaches for severe pulmonary tuberculosis. Bioorg Med Chem. 2022 Jan 1;53:116506. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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