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TAP2 - Tap2 transporter 2, ATP binding cassette subfamily B member Gene

Also Known as Cim; Abcb3

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 24812

Summary

Enables several functions, including TAP binding activity; adenyl ribonucleotide binding activity; and protein homodimerization activity. Contributes to MHC class I protein binding activity and peptide antigen binding activity. Involved in several processes, including peptide transport; positive regulation of antigen processing and presentation of peptide antigen via MHC class I; and protection from natural killer cell mediated cytotoxicity. Acts upstream of or within antigen processing and presentation of endogenous peptide antigen via MHC class I and positive regulation of T cell mediated cytotoxicity. Located in intracellular membrane-bounded organelle. Part of TAP complex. Human ortholog(s) of this gene implicated in several diseases, including MHC class I deficiency; aspirin-induced respiratory disease; autoimmune disease (multiple); cervical Cancer (multiple); and systemic scleroderma (multiple). Orthologous to human TAP2 (transporter 2, ATP binding cassette subfamily B member). [provided by Alliance of Genome Resources, Apr 2022]

TAP2 Products (1)

mRNA	Protein	Name
NM_032056.3	NP_114445.2	antigen peptide transporter 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ADP binding	IDA IDA: Inferred from direct assay	15611256	RGD
enables ATP binding	IDA IDA: Inferred from direct assay	12047747	RGD
enables ATP binding	IMP IMP: Inferred from mutant phenotype	14622282	RGD
contributes to MHC class I protein binding	IDA IDA: Inferred from direct assay	10508608	RGD
enables MHC class I protein binding	IDA IDA: Inferred from direct assay	12047747	RGD
enables TAP1 binding	IPI IPI: Inferred from physical interaction	12047747	RGD
enables TAP2 binding	IPI IPI: Inferred from physical interaction	12047747	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	16624807	RGD
enables nucleotide binding	IDA IDA: Inferred from direct assay	14622282	RGD
contributes to peptide antigen binding	IDA IDA: Inferred from direct assay	10508608	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	18802093	RGD
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	12047747	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	11595746	RGD
enables tapasin binding	IDA IDA: Inferred from direct assay	12047747	RGD
enables tapasin binding	IPI IPI: Inferred from physical interaction	12047747	RGD

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within antigen processing and presentation of endogenous peptide antigen via MHC class I	IDA IDA: Inferred from direct assay	1758495	RGD
involved in peptide transport	IMP IMP: Inferred from mutant phenotype	15611256	RGD
acts upstream of or within positive regulation of T cell mediated cytotoxicity	IDA IDA: Inferred from direct assay	1758495	RGD
involved in positive regulation of antigen processing and presentation of peptide antigen via MHC class I	IMP IMP: Inferred from mutant phenotype	1758495	RGD
involved in protection from natural killer cell mediated cytotoxicity	IMP IMP: Inferred from mutant phenotype	8120379	RGD
involved in protein-containing complex assembly	IDA IDA: Inferred from direct assay	12047747	RGD

Cellular Component GO Annotation	Evidence	References	Source
part of MHC class I peptide loading complex	IDA IDA: Inferred from direct assay	10508608	RGD
part of TAP complex	IDA IDA: Inferred from direct assay	11595746	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
antigen peptide transporter 2	APT2 ATP-binding cassette sub-family B member 3 Transporter 2 ABC (ATP binding cassette) transporter 2 ATP-binding cassette sub-family B transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12608	SEC14L3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14202	TAP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18500	Tap2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24053	Tap1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24982	Tap2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	TAP2	NCBI	NCBI:6891
Mus musculus	TAP2	NCBI	NCBI:21355