Tap2 - transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) Gene

Also Known as Y1; jas; APT2; Ham2; MTP2; PSF2; ABC18; Abcb3; Ham-2; Tap-2; RING11

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21355

Summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with Tap1 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in the human gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. [provided by RefSeq, Jul 2008]

Tap2 Products (1)

mRNA Protein Name
NM_011530.3 NP_035660.3 antigen peptide transporter 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables TAP1 binding IPI
IPI: Inferred from physical interaction
11133832 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
14735325 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of T cell mediated cytotoxicity IDA
IDA: Inferred from direct assay
1538753 MGI
acts upstream of T cell mediated cytotoxicity IMP
IMP: Inferred from mutant phenotype
16299293 MGI
acts upstream of or within antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent IDA
IDA: Inferred from direct assay
1538753 MGI
acts upstream of or within antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent IDA
IDA: Inferred from direct assay
1538753 MGI
acts upstream of or within antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent IMP
IMP: Inferred from mutant phenotype
16299293 MGI
acts upstream of or within positive regulation of T cell mediated cytotoxicity IDA
IDA: Inferred from direct assay
1538753 MGI
acts upstream of or within positive regulation of T cell mediated cytotoxicity IMP
IMP: Inferred from mutant phenotype
16299293 MGI
acts upstream of or within response to molecule of bacterial origin IMP
IMP: Inferred from mutant phenotype
16299293 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

antigen peptide transporter 2

  • ATP dependent transport protein family member

  • ATP-binding cassette sub-family B member 3

  • ATP-binding cassette, sub-family B (MDR/TAP), member 3

  • histocompatibility antigen modifier 2

  • transporter 2 ATP-binding cassette sub-family B

  • transporter 2, ABC (

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12608 SEC14L3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14202 TAP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18500 Tap2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24053 Tap1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24982 Tap2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tap2 NCBI NCBI:6891