TAP2 - transporter 2, ATP binding cassette subfamily B member Gene

Also Known as APT2; PSF2; ABC18; ABCB3; PSF-2; RING11; D6S217E

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6891

About TAP2

Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38): 6:32,821,831-32,838,739 (from NCBI)

This gene has 9 transcripts (splice variants), 1 gene allele, 159 orthologues, 10 paralogues and is associated with 2 phenotypes. Ubiquitous expression in appendix (RPKM 22.8), lymph node (RPKM 22.1) and 24 other tissues.

Summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules. [provided by RefSeq, Feb 2014]

TAP2 Products (3)

mRNA	Protein	Name
NM_000544.3	NP_000535.3	antigen peptide transporter 2 isoform 1
NM_001290043.2	NP_001276972.1	antigen peptide transporter 2 isoform 3
NM_018833.3	NP_061313.2	antigen peptide transporter 2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ABC-type peptide antigen transporter activity	IDA IDA: Inferred from direct assay	25377891	GOA
enables ABC-type peptide antigen transporter activity	IMP IMP: Inferred from mutant phenotype	1538751	GOA
enables ATP binding	IDA IDA: Inferred from direct assay	7673167	GOA
enables ATP binding	IMP IMP: Inferred from mutant phenotype	15793001	GOA
enables MHC class Ib protein binding	IPI IPI: Inferred from physical interaction	10605026	GOA
enables TAP1 binding	IPI IPI: Inferred from physical interaction	1538751	GOA
enables peptide antigen binding	IDA IDA: Inferred from direct assay	7500034	GOA
contributes to peptide transmembrane transporter activity	IGI IGI: Inferred from genetic interaction	7673167	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9427624	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in antigen processing and presentation of endogenous peptide antigen via MHC class I	IDA IDA: Inferred from direct assay	8496691	GOA
involved in antigen processing and presentation of endogenous peptide antigen via MHC class I	IMP IMP: Inferred from mutant phenotype	1538751	GOA
involved in antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent	IMP IMP: Inferred from mutant phenotype	1538751	GOA
involved in cytosol to endoplasmic reticulum transport	IMP IMP: Inferred from mutant phenotype	7538543	GOA
involved in peptide antigen transport	IDA IDA: Inferred from direct assay	8496691	GOA
involved in peptide antigen transport	IMP IMP: Inferred from mutant phenotype	1538751	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of MHC class I peptide loading complex	IDA IDA: Inferred from direct assay	17947644	GOA
part of TAP complex	IDA IDA: Inferred from direct assay	15518576	GOA
is active in endoplasmic reticulum	IDA IDA: Inferred from direct assay	22638925	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	7673167	GOA
located in membrane	IDA IDA: Inferred from direct assay	8955196	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TAP2 Protein Structure

ABC_membrane

ABC_tran

0
200
400
600
686 a.a.

Protein Preferred Names	Protein Names
antigen peptide transporter 2	ABC transporter, MHC 2

TAP2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TAP2	Q03519	TAP1	Homo sapiens	Q03518-2	Anti Bait CoIP	12213826
Intra	TAP2	Q03519	TAP1	Homo sapiens	Q03518	Anti Tag CoIP	28514442
Intra	TAP2	Q03519	TAP1	Homo sapiens	Q03518	Anti Bait CoIP	16828748
Intra	TAP2	Q03519	TAP1	Homo sapiens	Q03518	Anti Bait CoIP	19201886
Intra	TAP2	Q03519	TAP1	Homo sapiens	Q03518	Anti Bait CoIP	17055437
Intra	TAP2	Q03519	TAP1	Homo sapiens	Q03518	Anti Tag CoIP	33961781
Intra	TAP2	Q03519	TAPBP	Homo sapiens	O15533	Anti Bait CoIP	19201886
Intra	TAP2	Q03519	TAPBP	Homo sapiens	O15533	Anti Bait CoIP	12213826
Cross	TAP2	Q03519	bnl2a_ebvb9	Epstein-Barr virus	P0C739	Anti Bait CoIP	19201886

Cross: Cross-species interaction Intra: Intraspecies interaction

TAP2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P811224	TAP2 Antibody	WB, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Bare Lymphocyte Syndrome, Type I	Hla Class I Deficiency Mhc Class I Deficiency Bls, Type I Bare Lymphocyte Syndrome Type I Bare Lymphocyte Syndrome, Type I, Due To Tap2 Deficiency Blsi Mhc Class 1 Deficiency Major Histocompatibility Complex Class 1 Deficiency Bare Lymphocyte Syndrome 1 BLS1 Bls I Bls Type I Bl-1 Bare Lymphocyte Syndrome Type 1 Immunodeficiency By Defective Expression Of Hla - [Human Leukocyte Antigen] Class 1 Scid - [Severe Combined Immunodeficiency] Due To Absent Class 2 Hla Antigens Bls - [Bare Lymphocyte Syndrome] Nos
Immunodeficiency By Defective Expression Of Mhc Class I	Bare Lymphocyte Syndrome Type 1 Mhc Class I Deficiency
Spondylitis
Herpes Simplex	Herpes Simplex Infections Herpesvirus Hominis Disease Herpes Simplex Disease Herpesviral Infection Due To Herpes Simplex Infections Due To Simplex Virus Herpes Nos
Bare Lymphocyte Syndrome, Type Ii	Mhc Class Ii Deficiency Bare Lymphocyte Syndrome Major Histocompatibility Complex Class Ii Deficiency Bare Lymphocyte Syndrome 2 Bare Lymphocyte Syndrome Type 2 Severe Combined Immunodeficiency, Hla Class Ii-Negative Bare Lymphocyte Syndrome, Type Ii, Complementation Group C Bare Lymphocyte Syndrome, Type Ii, Complementation Group D Bare Lymphocyte Syndrome Type Ii Scid, Hla Class Ii-Negative Bare Lymphocyte Syndrome, Type Ii, Complementation Group A Bare Lymphocyte Syndrome, Type Ii, Complementation Group B Scid Due To Absent Class Ii Hla Antigens Hla Class 1 Deficiency Scid, Hla Class 2-Negative Bls Type Ii Bare Lymphocyte Syndrome Type 2, Complementation Group A Bare Lymphocyte Syndrome Type 2, Complementation Group E Severe Combined Immunodeficiency Bls, Type Ii Bls Bare Lymphocyte Syndrome, Type Ii, Complementation Group E Blsii Bls Type 1 Bls 2 Scid Due To Absence Of Class Ii Hla Antigens Severe Combined Immunodeficiency Due To Absent Class Ii Human Leukocyte Antigens Immunodeficiency By Defective Expression Of Mhc Class Ii BLS2 Bare Lymphocyte Syndrome Type Ii Complementation Group A Bare Lymphocyte Syndrome Type Ii Complementation Group B Bare Lymphocyte Syndrome Type Ii Complementation Group C Bare Lymphocyte Syndrome Type Ii Complementation Group D Bare Lymphocyte Syndrome Type Ii Complementation Group E Bls Ii Hereditary Mhc Class Ii Deficiency Hla Class Ii Deficient Combined Immunodeficiency Mhc-Ii Deficiency Scid Hla Class Ii-Negative Severe Combined Immunodeficiency Hla Class Ii-Negative Bl-2 Immunodeficiency By Defective Expression Of Hla Class 2 Hla Class 2-Negative Severe Combined Immunodeficiency
Echinococcosis	Hydatidosis Echinococcal Disease Echinococcosis Of Liver Hepatic Echinococcosis Hydatid Disease Liver Echinococcus Pulmonary Echinococcosis Hydatids Echinococcosis, Hepatic Echinococcosis, Pulmonary Unilocular Echinococcosis Echinococcus Disease Echinococcus Granulosus Infection Echinococcus Multilocularis Infection Dog Tapeworm Infection Echinococcus Granulosus Infestation Echinococciasis Cystic Echinococcosis
Type 1 Diabetes Mellitus	Diabetes Mellitus, Insulin-Dependent Diabetes Mellitus Type 1 IDDM Type 1 Diabetes Insulin-Dependent Diabetes Mellitus T1D Juvenile-Onset Diabetes Jod Diabetes Mellitus, Type 1 Diabetes Mellitus, Insulin-Dependent-1 Type I Diabetes Mellitus Autoimmune Diabetes Juvenile Diabetes Juvenile-Onset Diabetes Mellitus Diabetes, Insulin Dependent Insulin-Dependent Diabetes Mellitus-1 Diabetes Mellitus Insulin-Dependent Diabetes Autoimmune Diabetes Mellitus, Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 1, Susceptibility To Diabetes Type 1 Type I Diabetes Diabetes, Autoimmune T1dm - [Type 1 Diabetes Mellitus] Iddm - [Insulin Dependent Diabetes Mellitus] Type 1 Iddm Juvenile Diabetes Mellitus Without Compications Idiopathic Insulin-Dependent Diabetes Mellitus Without Complications Juvenile-Onset Diabetes Mellitus Without Compications Ketosis-Prone Diabetes Mellitus Without Compications Juvenile-Onset-Type Diabetes Mellitus Without Compications
Reactive Arthritis	Postdysenteric Arthropathy Reiter Disease Pira Reiter Syndrome Reiters Syndrome Arthritis, Reactive Fiessinger Leroy Reiter Syndrome Post-Bacterial Arthropathy Reiter'S Disease Post-Infectious Arthritis Post-Infectious Reactive Arthropathy Reiter'S Syndrome Arthritis Urethritica Fiessinger-Leroy Disease Polyarthritis Enterica Venereal Arthritis Arthritis Reactive Post-Dysenteric Arthropathy Arthritis, Venereal
Spondyloarthropathy 1	Ankylosing Spondylitis Spondyloarthropathy, Susceptibility To, 1 SPDA1 Marie-Strumpell Spondylitis Bechterew Syndrome Spa Spondylarthritis Ankylopoietica Reiter Syndrome Ankylosing Spondylitis, Susceptibility To Bekhterev Syndrome Bekhterev'S Disease Marie-Strumpell Disease Axial Spondylarthritis Bechterew Disease Marie-Struempell Disease Spondylitis Ankylopoietica Spondyloarthritis Spondyloarthritis Ankylopoietica Spas Ankylosing Spondylarthritis Psoriatic Arthritis Reactive Arthritis Rheumatoid Spondylitis Spondylitis Ankylosans Spondylitis Ankylosing Spondylitis, Ankylosing Spondylarthropathies Arthritis, Psoriatic Arthritis, Reactive
Diabetes Mellitus	Diabetes
Joubert Syndrome 4	JBTS4 Joubert Syndrome With Renal Defect Joubert Syndrome With Renal Anomalies Js-R Joubert Syndrome, Type 4
Severe Combined Immunodeficiency	Scid Severe Combined Immunodeficiency Disease Combined T And B Cell Inborn Immunodeficiency Immunodeficiency, Severe Combined Scid - [Severe Combined Immunodeficiencies]
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12608	SEC14L3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14202	TAP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18500	Tap2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24053	Tap1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24982	Tap2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TAP2	RGD	RGD:3818
Mus musculus	TAP2	MGD	MGI:98484
Others	TAP2	NCBI