GPX3 - glutathione peroxidase 3 Gene

Species: Bos taurus

Gene Type: protein coding
Gene ID: 281210

Summary

The protein encoded by this gene belongs to the Glutathione Peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is secreted, and is abundantly found in plasma. It is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2016]

GPX3 Products (1)

mRNA Protein Name
NM_174077.5 NP_776502.1 glutathione peroxidase 3 precursor
Protein Preferred Names Protein Names

glutathione peroxidase 3

  • GPx-3

  • GPx-P

  • GSHPx-3

  • GSHPx-P

  • glutathione peroxidase 3 (plasma)

  • plasma glutathione peroxidase

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B1016 Trapidil Inhibitor 98.0% Unkown
HY-B1016R Trapidil (Standard) Inhibitor / Unkown

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-116424 DYn-2 99.77% Unkown
HY-RS05766 GPX3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18479 Gpx3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24960 Gpx3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens GPX3 NCBI NCBI:2878