TRIT1 - tRNA isopentenyltransferase 1 Gene

Also Known as IPT; GRO1; IPPT; MOD5; hGRO1; IPTase; COXPD35

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 54802

About TRIT1

Cytogenetic location: 1p34.2 Genomic coordinates (GRCh38): 1:39,838,110-39,883,511 (from NCBI)

This gene has 16 transcripts (splice variants), 216 orthologues and is associated with 2 phenotypes. Ubiquitous expression in thyroid (RPKM 7.3), prostate (RPKM 6.7) and 25 other tissues.

Summary

This gene encodes a protein that that is targeted to the mitochondrion and modifies transfer RNAs (tRNAs) by adding a dimethylallyl group onto the adenine at position 37. This modification is important for maintaining the correct reading frame during protein translation. This gene is considered a tumor suppressor and its expression can decrease cell growth. Alternative splicing results in multiple transcripts variants, most of which are likely non-functional. [provided by RefSeq, Aug 2015]

TRIT1 Products (3)

mRNA	Protein	Name
NM_001312691.1	NP_001299620.1	tRNA dimethylallyltransferase isoform 2
NM_001312692.1	NP_001299621.1	tRNA dimethylallyltransferase isoform 3
NM_017646.6	NP_060116.2	tRNA dimethylallyltransferase isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA
enables tRNA dimethylallyltransferase activity	EXP EXP: Inferred from Experiment	24901367	GOA
enables tRNA dimethylallyltransferase activity	IDA IDA: Inferred from direct assay	24126054	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in mitochondrial tRNA modification	IDA IDA: Inferred from direct assay	24901367	GOA
involved in tRNA modification	IDA IDA: Inferred from direct assay	24126054	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in mitochondrion	IDA IDA: Inferred from direct assay	24901367	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIT1 Protein Structure

IPPT

zf-C2H2_jaz

0
100
200
300
400
467 a.a.

Protein Preferred Names	Protein Names
tRNA dimethylallyltransferase	IPP transferase

Related Diseases

Diseases	Alias
Combined Oxidative Phosphorylation Deficiency 35	COXPD35
Combined Oxidative Phosphorylation Deficiency
Sideroblastic Anemia With B-Cell Immunodeficiency, Periodic Fevers, And Developmental Delay	SIFD Congenital Sideroblastic Anemia-B-Cell Immunodeficiency-Periodic Fever-Developmental Delay Syndrome Sifd Syndrome
Cardiomyopathy, Infantile Hypertrophic	Infantile Hypertrophic Cardiomyopathy CMHI
Early Myoclonic Encephalopathy	Myoclonic Epilepsy Myoclonic Seizure Epilepsies, Myoclonic Epileptic Seizures - Myoclonic Epileptic Seizures, Myoclonic Myoclonia Epileptica Myoclonic Seizure Disorder Early Myoclonic Encephalopathy With Suppression-Bursts
Frontometaphyseal Dysplasia	Fmd Dysplasia, Frontometaphyseal
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly
Non-Syndromic X-Linked Intellectual Disability	X-Linked Non-Syndromic Intellectual Disability Non-Specific X-Linked Mental Retardation X-Linked Non-Specific Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15084	TRIT1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21798	Trit1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28314	Trit1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TRIT1	RGD	RGD:1304781
Canis familiaris	TRIT1	VGNC	VGNC:47848
Macaca mulatta	TRIT1	VGNC	VGNC:79239
Mus musculus	TRIT1	MGD	MGI:1914216
Felis catus	TRIT1	VGNC	VGNC:66563
Bos taurus	TRIT1	VGNC	VGNC:36363
Others	TRIT1	NCBI