UBE2O - ubiquitin conjugating enzyme E2 O Gene

Also Known as E2-230K

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 63893

About UBE2O

Cytogenetic location: 17q25.1 Genomic coordinates (GRCh38): 17:76,389,456-76,453,152 (from NCBI)

This gene has 6 transcripts (splice variants), 186 orthologues and 24 paralogues. Ubiquitous expression in brain (RPKM 12.9), testis (RPKM 11.1) and 25 other tissues.

Summary

Enables ubiquitin conjugating enzyme activity and ubiquitin protein Ligase activity. Involved in positive regulation of BMP signaling pathway; protein ubiquitination; and retrograde transport, endosome to Golgi. Located in cytoplasm and nuclear body. [provided by Alliance of Genome Resources, Apr 2022]

UBE2O Products (1)

mRNA Protein Name
NM_022066.4 NP_071349.3 (E3-independent) E2 ubiquitin-conjugating enzyme

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19549727 GOA
enables ubiquitin conjugating enzyme activity IDA
IDA: Inferred from direct assay
23455153 GOA
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
23455153 GOA
enables ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
23455153 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of BMP signaling pathway IDA
IDA: Inferred from direct assay
23455153 GOA
involved in protein K63-linked ubiquitination IMP
IMP: Inferred from mutant phenotype
23452853 GOA
involved in protein monoubiquitination IDA
IDA: Inferred from direct assay
23455153 GOA
involved in retrograde transport, endosome to Golgi IMP
IMP: Inferred from mutant phenotype
23452853 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
24703950 GOA
located in nucleus IDA
IDA: Inferred from direct assay
24703950 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBE2O Protein Structure

UQ_con

UQ_con: Ubiquitin-conjugating enzyme (958 - 1091)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1200
  • 1292 a.a.
Protein Preferred Names Protein Names

(E3-independent) E2 ubiquitin-conjugating enzyme

  • E2/E3 hybrid ubiquitin-protein ligase UBE2O

UBE2O Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
UBE2O Q9C0C9 SFMBT2 Homo sapiens Q5VUG0
Y2H Prey Pooling
32296183
Intra
UBE2O Q9C0C9 SFMBT2 Homo sapiens Q5VUG0
Y2H Array
32296183
Intra
UBE2O Q9C0C9 PRKN Homo sapiens O60260-5
Y2H Pooling
32814053
Intra
UBE2O Q9C0C9 PRKN Homo sapiens O60260-5
Validated Y2H
32814053
Intra
UBE2O Q9C0C9 PRKN Homo sapiens O60260-5
Y2H Array
32814053
Intra
UBE2O Q9C0C9 GNB2 Homo sapiens P62879
Y2H Array
32814053
Intra
UBE2O Q9C0C9 GNB2 Homo sapiens P62879
Validated Y2H
32814053
Intra
UBE2O Q9C0C9 GNB2 Homo sapiens P62879
Y2H Pooling
32814053
Cross
UBE2O Q9C0C9 Smad6 Mus musculus O35182
Anti Tag CoIP
23455153
Cross
UBE2O Q9C0C9 Smad7 Mus musculus O35253
Anti Tag CoIP
23455153
Intra
UBE2O Q9C0C9 APPL1 Homo sapiens Q9UKG1
Validated Y2H
32296183
Intra
UBE2O Q9C0C9 APPL1 Homo sapiens Q9UKG1
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Pontocerebellar Hypoplasia, Type 2a

  • Pontocerebellar Hypoplasia Type 2a

  • PCH2A

  • Pch2

  • Pontocerebellar Hypoplasia With Progressive Cerebral Atrophy

  • Volendam Neurodegenerative Disease

  • Pontocerebellar Hypoplasia 2a

  • Hypoplasia, Pontocerebellar, Type 2a
Pontocerebellar Hypoplasia, Type 16

  • PCH16

  • Pontocerebellar Hypoplasia Type 16

  • Pontocerebellar Hypoplasia 16

  • Doid:0112333
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-128912 Arborinine Inhibitor 99.87% Unkown
HY-RS15357 UBE2O Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20123 Ube2o Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26627 Ube2o Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus UBE2O MGD MGI:2444266
Macaca mulatta UBE2O VGNC VGNC:79813
Felis catus UBE2O VGNC VGNC:99567
Bos taurus UBE2O VGNC VGNC:36591
Rattus norvegicus UBE2O RGD RGD:1310297
Canis familiaris UBE2O VGNC VGNC:48060
Others UBE2O NCBI