2. Gene
  3. UBE2O - ubiquitin conjugating enzyme E2 O Gene

UBE2O - ubiquitin conjugating enzyme E2 O Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as E2-230K

Gene ID: 63893 | Gene type: protein coding

About UBE2O

Cytogenetic location: 17q25.1 Genomic coordinates (GRCh38): 17:76,389,456-76,453,152 (from NCBI)

This gene has 6 transcripts (splice variants), 186 orthologues and 24 paralogues. Ubiquitous expression in brain (RPKM 12.9), testis (RPKM 11.1) and 25 other tissues.

Summary

Enables ubiquitin conjugating Enzyme activity and ubiquitin protein ligase activity. Involved in positive regulation of BMP signaling pathway; protein ubiquitination; and retrograde transport, endosome to Golgi. Located in cytoplasm and nuclear body. [provided by Alliance of Genome Resources, Apr 2022]

UBE2O Products(1)

mRNA Protein Name
NM_022066.4 NP_071349.3 (E3-independent) E2 ubiquitin-conjugating enzyme

UBE2O Protein Structure

UQ_con

UQ_con: Ubiquitin-conjugating enzyme (958 - 1091)

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  • 1292 a.a.
Protein Preferred Names Protein Names

(E3-independent) E2 ubiquitin-conjugating enzyme

E2/E3 hybrid ubiquitin-protein ligase UBE2O

Related Diseases

Diseases Alias
Pontocerebellar Hypoplasia, Type 2a

Pontocerebellar Hypoplasia Type 2a

PCH2A

Pch2

Pontocerebellar Hypoplasia With Progressive Cerebral Atrophy

Volendam Neurodegenerative Disease

Pontocerebellar Hypoplasia 2a

Hypoplasia, Pontocerebellar, Type 2a
Pontocerebellar Hypoplasia, Type 16

PCH16

Pontocerebellar Hypoplasia Type 16

Pontocerebellar Hypoplasia 16

Doid:0112333
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-128912 Arborinine Inhibitor / Unkown
HY-RS15357 UBE2O Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus UBE2O MGD MGI:2444266
Macaca mulatta UBE2O VGNC VGNC:79813
Felis catus UBE2O VGNC VGNC:99567
Bos taurus UBE2O VGNC VGNC:36591
Rattus norvegicus UBE2O RGD RGD:1310297
Canis familiaris UBE2O VGNC VGNC:48060
Others UBE2O NCBI