Smad7 - SMAD family member 7 Gene

Also Known as Madh7

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17131

Summary

Enables Collagen binding activity. Involved in several processes, including circulatory system development; negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains; and negative regulation of protein phosphorylation. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; negative regulation of BMP signaling pathway; and transforming growth factor beta receptor signaling pathway. Located in nucleus. Part of protein-containing complex. Is expressed in several structures, including cardiovascular system; central nervous system; early conceptus; genitourinary system; and inner ear. Human ortholog(s) of this gene implicated in colorectal Cancer and pancreatic adenocarcinoma. Orthologous to human SMAD7 (Smad Family member 7). [provided by Alliance of Genome Resources, Apr 2022]

Smad7 Products (1)

mRNA Protein Name
NM_001042660.1 NP_001036125.1 mothers against decapentaplegic homolog 7

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables collagen binding IPI
IPI: Inferred from physical interaction
14559231 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16601693 MGI
Biological Process GO Annotation Evidence References Source
involved in artery morphogenesis IMP
IMP: Inferred from mutant phenotype
18952608 MGI
acts upstream of or within cellular response to leukemia inhibitory factor IEP
IEP: Inferred from expression pattern
20439489 MGI
involved in cellular response to transforming growth factor beta stimulus IMP
IMP: Inferred from mutant phenotype
18593713 MGI
acts upstream of or within negative regulation of BMP signaling pathway IDA
IDA: Inferred from direct assay
19850029 MGI
involved in negative regulation of SMAD protein signal transduction IMP
IMP: Inferred from mutant phenotype
18952608 MGI
involved in negative regulation of T cell cytokine production IMP
IMP: Inferred from mutant phenotype
25642768 MGI
involved in negative regulation of T-helper 17 cell differentiation IMP
IMP: Inferred from mutant phenotype
25642768 MGI
involved in negative regulation of T-helper 17 type immune response IMP
IMP: Inferred from mutant phenotype
25642768 MGI
involved in negative regulation of chondrocyte proliferation IDA
IDA: Inferred from direct assay
29503843 MGI
involved in negative regulation of ossification IDA
IDA: Inferred from direct assay
29503843 MGI
involved in negative regulation of peptidyl-serine phosphorylation IMP
IMP: Inferred from mutant phenotype
18593713 MGI
involved in negative regulation of peptidyl-threonine phosphorylation IMP
IMP: Inferred from mutant phenotype
18593713 MGI
involved in positive regulation of cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
18593713 MGI
involved in positive regulation of chondrocyte hypertrophy IDA
IDA: Inferred from direct assay
29503843 MGI
involved in regulation of cardiac muscle contraction IMP
IMP: Inferred from mutant phenotype
18952608 MGI
involved in regulation of transforming growth factor beta receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
18952608 MGI
involved in regulation of ventricular cardiac muscle cell membrane depolarization IMP
IMP: Inferred from mutant phenotype
18952608 MGI
acts upstream of or within transforming growth factor beta receptor signaling pathway IDA
IDA: Inferred from direct assay
11557747 MGI
involved in ureteric bud development IEP
IEP: Inferred from expression pattern
14656760 MGI
involved in ventricular cardiac muscle tissue morphogenesis IMP
IMP: Inferred from mutant phenotype
18952608 MGI
involved in ventricular septum morphogenesis IMP
IMP: Inferred from mutant phenotype
18952608 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
16601693 MGI
part of protein-containing complex IDA
IDA: Inferred from direct assay
16601693 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mothers against decapentaplegic homolog 7

  • MAD homolog 7

  • MAD homolog 8

  • SMAD 7

  • madh8

  • mothers against DPP homolog 7

  • mothers against DPP homolog 8

  • mothers against decapentaplegic homolog 8

Smad7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Smad7 O35253 Sirt1 Mus musculus Q923E4
Anti Tag CoIP
17098745
Intra
Smad7 O35253 Sirt1 Mus musculus Q923E4
Anti Bait CoIP
17098745
Intra
Smad7 O35253 Axin1 Mus musculus O35625
Anti Tag CoIP
16601693
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-145721A Mongersen sodium 99.61% Phase 3
HY-145721 Mongersen Inhibitor 98.57% Phase 3

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0439 Asiaticoside 99.67% Unkown
HY-107802 Breviscapine 99.13% Unkown
HY-170791 CIB-L43 99.71% Unkown
HY-120268A SLM6031434 hydrochloride Inhibitor 99.1% Unkown
HY-RS13398 SMAD7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-120268 SLM6031434 Inhibitor / Unkown
HY-175662 TGF-β/Smad-IN-2 Inhibitor / Unkown
HY-N13208 Stevia Powder / Unkown
HY-RS18408 Smad7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24889 Smad7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Smad7 NCBI NCBI:4092