GCM1 - glial cells missing transcription factor 1 Gene

Also Known as GCMA; hGCMa

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8521

About GCM1

Cytogenetic location: 6p12.1 Genomic coordinates (GRCh38): 6:53,126,961-53,148,841 (from NCBI)

This gene has 1 transcript (splice variant), 130 orthologues and 1 paralogue. Biased expression in placenta (RPKM 5.9), testis (RPKM 0.6) and 1 other tissue.

Summary

This gene encodes a DNA-binding protein with a gcm-motif (glial cell missing motif). The encoded protein is a homolog of the Drosophila glial cells missing gene (gcm). This protein binds to the GCM-motif (A/G)CCCGCAT, a novel sequence among known targets of DNA-binding proteins. The N-terminal DNA-binding domain confers the unique DNA-binding activity of this protein. [provided by RefSeq, Jul 2008]

GCM1 Products (1)

mRNA Protein Name
NM_003643.4 NP_003634.2 chorion-specific transcription factor GCMa

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
15385555 GOA
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
15385555 GOA
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
23867755 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
15385555 GOA
enables histone deacetylase binding IPI
IPI: Inferred from physical interaction
23867755 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
23651062 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
27917469 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15385555 GOA
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
15385555 GOA
involved in regulation of cell differentiation involved in embryonic placenta development IMP
IMP: Inferred from mutant phenotype
19219068 GOA
involved in transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
23867755 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
23867755 GOA
part of transcription regulator complex IDA
IDA: Inferred from direct assay
15385555 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GCM1 Protein Structure

GCM

GCM: GCM motif protein (29 - 169)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 436 a.a.
Protein Preferred Names Protein Names

chorion-specific transcription factor GCMa

  • GCM motif protein 1

GCM1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GCM1 Q9NP62 DLX3 Homo sapiens O60479
Anti Bait CoIP
28515447
Intra
GCM1 Q9NP62 GATA3 Homo sapiens P23771
Confocal
26899996
Intra
GCM1 Q9NP62 GATA3 Homo sapiens P23771
Anti Bait CoIP
26899996
Intra
GCM1 Q9NP62 FBXW2 Homo sapiens Q9UKT8
Pull Down
23651062
Intra
GCM1 Q9NP62 FBXW2 Homo sapiens Q9UKT8
Anti Tag CoIP
23651062
Cross: Cross-species interaction Intra: Intraspecies interaction

GCM1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P89694 GCM1 Antibody (YA9038) WB, ICC/IF, IF-Tissue, IP, ELISA human

Related Diseases

Diseases Alias
Cardiomyopathy, Familial Restrictive, 2

  • RCM2

  • Restrictive Cardiomyopathy 2

  • Familial Restrictive Cardiomyopathy 2

  • Cardiomyopathy, Restrictive, Familial, Type 2
Placental Choriocarcinoma

  • Choriocarcinoma Of The Placenta
Gestational Choriocarcinoma

  • Gestational Chorionepithelioma

  • Molar Pregnancy With Choriocarcinoma
Cardiomyopathy, Familial Restrictive, 1

  • RCM1

  • Restrictive Cardiomyopathy 1

  • Rcm

  • Familial Restrictive Cardiomyopathy 1

  • Cardiomyopathy, Familial Restrictive 1

  • Cardiomyopathy, Restrictive, Familial, Type 1

  • Rcm-1
Pre-Eclampsia

  • Preeclampsia

  • Gestational Hypertension

  • Hypertension Induced By Pregnancy

  • Pre-Eclamptic Toxaemia

  • Pregnancy Associated Hypertension

  • Proteinuric Hypertension Of Pregnancy

  • Hypertension, Pregnancy-Induced, Susceptibility To

  • Preeclampsia/Eclampsia

  • Pregnancy Toxemia

  • Toxaemia Of Pregnancy

  • Gestational Proteinuric Hypertension

  • Pregnancy-Induced Hypertension

  • Toxemia Of Pregnancy

  • Preeclampsia, Susceptibility To

  • Transient Hypertension Of Pregnancy

  • Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria

  • Gestational Hypertension Nos

  • Mild Proteinuric Hypertension Of Pregnancy

  • Pih - [Pregnancy-Induced Hypertension]

  • Pregnancy-Induced Hypertension Nos

  • Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria

  • Pe - [Pre-Eclampsia]

  • Pre-Eclampsia Nos

  • Pre-Eclamptic Nos

  • Pregnancy Pre-Eclampsia

  • Puerperal Pre-Eclampsia

  • Pre-Eclampsia Toxaemia

  • Toxaemia In Pregnancy

  • Pet - [Pre-Eclamptic Toxaemia]

  • Maternal Toxaemia
Neural Tube Defects

  • Spina Bifida

  • Neural Tube Defect

  • NTD

  • Neural Tube Defects, Susceptibility To

  • Spinal Dysraphism

  • Spina Bifida, Susceptibility To

  • Rachischisis

  • Cleft Spine

  • Open Spine

  • Hydrocele Spinalis

  • Neural Tube Defect Nos

  • Sb - [Spina Bifida]

  • Spinal Hernia Nos

  • Spinal Fissure Nos
Placenta Disease

  • Placenta Diseases

  • Placenta Disorder

  • Pregnancy Complications

  • Placenta Disorders
Persistent Fetal Circulation Syndrome

  • Persistent Fetal Circulation

  • Fetal Circulation

  • Persistent Pulmonary Hypertension Of The Newborn

  • Congenital Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins

  • Persistent Foetal Circulation

  • Persistent Foetal Circulation Syndrome

  • Pfc - [Persistent Fetal Circulation] Syndrome

  • Pphn - [Persistent Pulmonary Hypertension Of The Newborn]

  • Newborn Pulmonary Hypertension

  • Primary Pulmonary Hypertension Of Newborn
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-130229 (±)5,6-DHET lactone / Unkown
HY-RS05335 GCM1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus GCM1 MGD MGI:108045
Macaca mulatta GCM1 VGNC VGNC:72903
Rattus norvegicus GCM1 RGD RGD:61852
Bos taurus GCM1 VGNC VGNC:29291
Felis catus GCM1 VGNC VGNC:102428
Canis familiaris GCM1 VGNC VGNC:41149
Others GCM1 NCBI