RET-IN-7
Based on 1 Customer Validation
RET-IN-7 demonstrates potent in vitro RET kinase inhibition and robust in vivo efficacy in RET-driven tumor xenografts upon multiday dosing in mice.
For research use only. We do not sell to patients.
- Purity: 98.00%
- CAS No.: 2763386-05-4
- Formula: C22H24ClFN6O2
- Molecular Weight:458.92
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Kinase Inhibitor Library
HY-L009
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Protein Tyrosine Kinase Compound Library
HY-L016
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Anti-Cancer Compound Library
HY-L025
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Anti-Lung Cancer Compound Library
HY-L075
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Anti-Liver Cancer Compound Library
HY-L101
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Membrane Protein-targeted Compound Library
HY-L149
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Membrane Receptor-targeted Compound Library
HY-L150
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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Anti-Brain Cancer Compound Library
HY-L188
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Protein Kinase Compound Library
HY-L196
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High-Throughput Bioactive Compound Library
HY-L205
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Posttranslational Modification Library
HY-L226
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BaF3 | IC50 |
4.1 μM
Compound: 1
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Antiproliferative activity against mouse BaF3 cells assessed as reduction in cell proliferation incubated for 48 hrs by cell proliferation assay
Antiproliferative activity against mouse BaF3 cells assessed as reduction in cell proliferation incubated for 48 hrs by cell proliferation assay
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[PMID: 34917254] |
Chemical Information
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CAS No. 2763386-05-4
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Appearance Solid
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Molecular Weight 458.92
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Formula C22H24ClFN6O2
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Color Off-white to light yellow
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SMILES
O=C(NC12CCC(CC1)(CC2)N3C=C(C4=C3N=CN=C4N)C5=C(F)C=C(Cl)C(N)=C5)OC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 16.67 mg/mL (36.32 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Purity & Documentation
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Data Sheet (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1790 mL | 10.8951 mL | 21.7903 mL | 54.4757 mL |
| 5 mM | 0.4358 mL | 2.1790 mL | 4.3581 mL | 10.8951 mL | |
| 10 mM | 0.2179 mL | 1.0895 mL | 2.1790 mL | 5.4476 mL | |
| 15 mM | 0.1453 mL | 0.7263 mL | 1.4527 mL | 3.6317 mL | |
| 20 mM | 0.1090 mL | 0.5448 mL | 1.0895 mL | 2.7238 mL | |
| 25 mM | 0.0872 mL | 0.4358 mL | 0.8716 mL | 2.1790 mL | |
| 30 mM | 0.0726 mL | 0.3632 mL | 0.7263 mL | 1.8159 mL |
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