Bovine Serum Albumin
Based on 54 publication(s) in Google Scholar
Bovine Serum Albumin (BSA) is a 583-residue protein consisting of three homologous all-α domains, organized in a heart-shaped structure. BSA is a globular protein that is used in numerous biochemical applications.
For research use only. We do not sell to patients.
- Purity: 98.2%
- CAS No.: 9048-46-8
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocol
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Bovine Serum Albumin
More- Cancer Res. 2026 Jan 9. [Abstract]
- Nat Commun. 2026 Feb 12;17(1):2681. [Abstract]
- Sci Transl Med. 2024 Jan 24;16(731):eadf4590. [Abstract]
- J Extracell Vesicles. 2025 Sep;14(9):e70162. [Abstract]
- Autophagy. 2026 Jan 19:1-16. [Abstract]
- Adv Sci (Weinh). 2025 Mar 27:e2413709. [Abstract]
- J Nanobiotechnology. 2025 Oct 31;23(1):695. [Abstract]
- EBioMedicine. 2021 Mar:65:103283. [Abstract]
- Mater Today Bio. 2025 Apr 4:32:101730. [Abstract]
- Cell Mol Biol Lett. 2024 Feb 17;29(1):26. [Abstract]
- Food Chem. 2023 Mar 1:403:134399. [Abstract]
- Cell Death Dis. 2022 Aug 9;13(8):695. [Abstract]
- Int J Biol Macromol. 2019 Aug 1:134:622-630. [Abstract]
- EMBO Mol Med. 2025 Jul 24. [Abstract]
- Free Radic Biol Med. 2025 Aug 13:240:183-196. [Abstract]
- Br J Cancer. 2022 Nov;127(8):1411-1423. [Abstract]
- Sci Signal. 2022 May 24;15(735):eabm6265. [Abstract]
- Int J Mol Med. 2026 May;57(5):114. [Abstract]
- Int J Mol Med. 2026 Jan;57(1):26. [Abstract]
- Chem Biol Interact. 2023 Jun 1:378:110501. [Abstract]
- Chin J Phys. 2026 Jun 20.
- Cancer Metab. 2025 Aug 14;13(1):37. [Abstract]
- Inflammopharmacology. 2023 Apr;31(2):915-926. [Abstract]
- Int J Pharm. 2024 Mar 25:653:123929. [Abstract]
- Expert Opin Drug Discov. 2025 Aug;20(8):1075-1092. [Abstract]
- J Zhejiang Univ Sci B. 2023 Mar 15;24(3):232-247. [Abstract]
- Bioorg Chem. 2020 Dec:105:104367. [Abstract]
- Molecules. 2024 Jul 30;29(15):3590. [Abstract]
- Sci Rep. 2026 Jan 6;16(1):3716. [Abstract]
- ACS Chem Biol. 2026 Mar 20;21(3):601-612. [Abstract]
- BMC Genomics. 2025 Mar 28;26(1):305. [Abstract]
- Biochim Biophys Acta Mol Cell Res. 2025 Jan 27:119911. [Abstract]
- Mol Med Rep. 2025 Aug;32(2):211. [Abstract]
- Mol Med Rep. 2025 May;31(5):126. [Abstract]
- Microb Pathog. 2023 Sep:182:106244. [Abstract]
- Mol Med Rep. 2018 Mar;17(3):3877-3883. [Abstract]
- Andrology. 2024 May 22. [Abstract]
- Phytochemistry. 2019 Sep:165:112025. [Abstract]
- Cardiovasc Drugs Ther. 2025 May 22. [Abstract]
- Arch Biochem Biophys. 2025 Aug 28:773:110603. [Abstract]
- ACS Food Sci Technol. 2024 Jan 17.
- BMC Vet Res. 2025 Mar 19;21(1):184. [Abstract]
- Toxicon. 2025 Jan 7:108233. [Abstract]
- Immunobiology. 2025 Mar 12;230(3):152891. [Abstract]
- J Neurosci Methods. 2018 Sep 1:307:240-247. [Abstract]
- Biochem Biophys Res Commun. 2025 Jun 10:776:152184. [Abstract]
- Eur J Histochem. 2025 Apr 7;69(2). [Abstract]
- J Chem Neuroanat. 2024 Mar:136:102375. [Abstract]
- Kidney Blood Press Res. 2023;48(1):261-276. [Abstract]
- Neurol Res. 2024 Jul 9:1-12. [Abstract]
- Egypt J Med Hum Genet. 2025 Dec 22;26(1):189.
- Res Sq. 2025 Jul 21.
- Northeastern Illinois University. 2024.
- Chinese Pharmacological Bulletin. 2018 May; 34(5): 620-626.
Biological Activity
Bovine serum albumin (BSA) is a 583-residue protein consisting of three homologous all-α domains, organized in a heart-shaped structure. Bovine serum albumin constitutes ca. 60% of all plasma protein and binds and transports a large number of physiological and non-physiological ligands. Bovine serum albumin contains 17 disulfide bonds and one unpaired cysteine (Cys34), which facilitates dimerization and also influences higher-order association, since the rate of aggregation is slowed down if Cys34 is covalently bound to another compound. MTT assay for fibril cytotoxicity shows Bovine Serum Albumin is beneficial for cell growth irrespective of its aggregated state. Lack of cytotoxicity is confirmed by membrane permeabilization assays. In the subsequent 40 h, an increase in the viability of the treated cells of 300-400% is observed, indicating that the cells incubated with Bovine Serum Albumin achieve a higher viability than the untreated cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 9048-46-8
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Appearance Solid
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Color White to light yellow
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SMILES
S=B[*]
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Synonyms
Albumin bovine serum; BSA
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (54)
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Journal Impact Factor
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Most Recent
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Cancer Res
KLF5 Activation Promotes Malignant Transformation to Drive Development of Lung Squamous Cell Carcinoma. [Abstract]2026 Jan 9. PMID: 41512183 -
Nat Commun
2026 Feb 12;17(1):2681. PMID: 41680151 -
Sci Transl Med
Single-cell atlas of human infrapatellar fat pad and synovium implicates APOE signaling in osteoarthritis pathology. [Abstract]2024 Jan 24;16(731):eadf4590. PMID: 38266107 -
J Extracell Vesicles
Targeted Blockage of Pathological Extracellular Vesicles and Particles From Fibroblast-Like Synoviocytes for Osteoarthritis Relief: Proteomic Analysis and Cellular Effect. [Abstract]2025 Sep;14(9):e70162. PMID: 40919882 -
Autophagy
Metabolites released from apoptotic cells in central nervous system orchestrates the pathological process of Alzheimer disease through improving autophagy. [Abstract]2026 Jan 19:1-16. PMID: 41518198 -
Adv Sci (Weinh)
UGDH Lactylation Aggravates Osteoarthritis by Suppressing Glycosaminoglycan Synthesis and Orchestrating Nucleocytoplasmic Transport to Activate MAPK Signaling. [Abstract]2025 Mar 27:e2413709. PMID: 40150862 -
J Nanobiotechnology
A TEMPO-loaded DNA hydrogel enabling integrated early diagnosis and treatment of osteoarthritis. [Abstract]2025 Oct 31;23(1):695. PMID: 41174784 -
EBioMedicine
2021 Mar:65:103283. PMID: 33714889 -
Mater Today Bio
Bioactive deproteinized bovine bone mineral based on self-assembled albumin nanoparticles promoted bone regeneration via activation of Wnt/β-catenin pathway. [Abstract]2025 Apr 4:32:101730. PMID: 40275954 -
Cell Mol Biol Lett
High-content image screening to identify chemical modulators for peroxisome and ferroptosis. [Abstract]2024 Feb 17;29(1):26. PMID: 38368371 -
Food Chem
Electrochemical sensor for detecting streptomycin in milk based on label-free aptamer chain and magnetic adsorption. [Abstract]2023 Mar 1:403:134399. PMID: 36182859 -
Cell Death Dis
Circular RNA circNFKB1 promotes osteoarthritis progression through interacting with ENO1 and sustaining NF-κB signaling. [Abstract]2022 Aug 9;13(8):695. PMID: 35945200 -
Int J Biol Macromol
Natural constituents of St. John's Wort inhibit the proteolytic activity of human thrombin. [Abstract]2019 Aug 1:134:622-630. PMID: 31047931 -
EMBO Mol Med
De novo pyrimidine synthesis is a collateral metabolic vulnerability in NF2-deficient mesothelioma. [Abstract]2025 Jul 24. PMID: 40707702 -
Free Radic Biol Med
2025 Aug 13:240:183-196. PMID: 40816648 -
Br J Cancer
Somatic mutations in DCC are associated with genomic instability and favourable outcomes in melanoma patients treated with immune checkpoint inhibitors. [Abstract]2022 Nov;127(8):1411-1423. PMID: 35871235 -
Sci Signal
The lncRNA PILA promotes NF-κB signaling in osteoarthritis by stimulating the activity of the protein arginine methyltransferase PRMT1. [Abstract]2022 May 24;15(735):eabm6265. PMID: 35609127 -
Int J Mol Med
2026 May;57(5):114. PMID: 41789656 -
Int J Mol Med
MOTS‑c protects against placental injury via Nrf2 activation in hypoxia‑induced intrauterine growth restriction mice. [Abstract]2026 Jan;57(1):26. PMID: 41268602 -
Chem Biol Interact
Discovery of seven-membered ring berberine analogues as highly potent and specific hCES2A inhibitors. [Abstract]2023 Jun 1:378:110501. PMID: 37080375 -
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Cancer Metab
NSUN2 promotes colorectal cancer progression by stabilizing PHGDH mRNA to promote serine metabolism reprogramming. [Abstract]2025 Aug 14;13(1):37. PMID: 40814066 -
Inflammopharmacology
Synovial mesenchymal stem cell-derived exosomal microRNA-320c facilitates cartilage damage repair by targeting ADAM19-dependent Wnt signalling in osteoarthritis rats. [Abstract]2023 Apr;31(2):915-926. PMID: 36862227 -
Int J Pharm
Selenium nanoparticles/carboxymethyl chitosan/alginate antioxidant hydrogel for treating steroid-induced osteonecrosis of the femoral head. [Abstract]2024 Mar 25:653:123929. PMID: 38387817 -
Expert Opin Drug Discov
In-silico guided identification and in-vitro studies of potential FFAR4 agonists for type 2 diabetes mellitus therapy. [Abstract]2025 Aug;20(8):1075-1092. PMID: 40580106 -
J Zhejiang Univ Sci B
2023 Mar 15;24(3):232-247. PMID: 36915999 -
Bioorg Chem
Discovery of natural alkaloids as potent and selective inhibitors against human carboxylesterase 2. [Abstract]2020 Dec:105:104367. PMID: 33080495 -
Molecules
Enhancing Functional Properties and Protein Structure of Almond Protein Isolate Using High-Power Ultrasound Treatment. [Abstract]2024 Jul 30;29(15):3590. PMID: 39124994 -
Sci Rep
2026 Jan 6;16(1):3716. PMID: 41491809 -
ACS Chem Biol
Li-BrU-seq: A Low-Input and Simplified Metabolic Labeling Method for Nascent RNA Sequencing. [Abstract]2026 Mar 20;21(3):601-612. PMID: 41773915 -
BMC Genomics
Aromatase reduces sperm motility by down-regulating the expression of proteins related to ATP synthesis in seminal plasma extracellular vesicles. [Abstract]2025 Mar 28;26(1):305. PMID: 40155807 -
Biochim Biophys Acta Mol Cell Res
MARCH5 ameliorates aortic valve calcification via RACGAP1-DRP1 associated mitochondrial quality control. [Abstract]2025 Jan 27:119911. PMID: 39880131 -
Mol Med Rep
2025 Aug;32(2):211. PMID: 40417885 -
Mol Med Rep
Exosomes derived from baicalin‑pretreated mesenchymal stem cells mitigate atherosclerosis by regulating the SIRT1/NF‑κB signaling pathway. [Abstract]2025 May;31(5):126. PMID: 40084693 -
Microb Pathog
Oxysophocarpine suppresses TRAF6 level to ameliorate oxidative stress and inflammatory factors secretion in mice with dextran sulphate sodium (DSS) induced-ulcerative colitis. [Abstract]2023 Sep:182:106244. PMID: 37423495 -
Mol Med Rep
Puerarin protects endothelial progenitor cells from damage of angiotensin II via activation of ERK1/2‑Nrf2 signaling pathway. [Abstract]2018 Mar;17(3):3877-3883. PMID: 29359784 -
Andrology
Cellular mechanism underlying leptin-induced anion secretion of rat epididymal epithelial cells. [Abstract]2024 May 22. PMID: 38778669 -
Phytochemistry
Anthraquinones from Cassiae semen as thrombin inhibitors: in vitro and in silico studies. [Abstract]2019 Sep:165:112025. PMID: 31207449 -
Cardiovasc Drugs Ther
Midkine Promote Atherosclerosis by Regulating the Expression of ATP-Binding Cassette Transporter A1 via Activator Protein-1. [Abstract]2025 May 22. PMID: 40402391 -
Arch Biochem Biophys
MALAT1 elevates the secretion of Th2 cytokines via miR-422a/NUP155 axis in allergic rhinitis mice. [Abstract]2025 Aug 28:773:110603. PMID: 40885462 -
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BMC Vet Res
2025 Mar 19;21(1):184. PMID: 40108665 -
Toxicon
Ursolic acid enhances radiosensitivity in esophageal squamous cell carcinoma by modulating p53/SLC7A11/GPX4 pathway-mediated ferroptosis. [Abstract]2025 Jan 7:108233. PMID: 39788329 -
Immunobiology
Different doses of hydroxychloroquine regulate the structure of intestinal flora and glycosyltransferase activity in rats with IgA nephropathy. [Abstract]2025 Mar 12;230(3):152891. PMID: 40112730 -
J Neurosci Methods
Insulin and heparin-binding epidermal growth factor-like growth factor synergistically promote astrocyte survival and proliferation in serum-free medium. [Abstract]2018 Sep 1:307:240-247. PMID: 29890195 -
Biochem Biophys Res Commun
Engineered MAP30ER: A plant toxin-derived platform for EGFR-Targeted delivery of protein and chemotherapeutic payloads. [Abstract]2025 Jun 10:776:152184. PMID: 40517671 -
Eur J Histochem
Knockdown of miR-411-3p induces M2 macrophage polarization and promotes colorectal cancer progression by regulation of MMP7. [Abstract]2025 Apr 7;69(2). PMID: 40322788 -
J Chem Neuroanat
Solifenacin promotes remyelination in cuprizone mouse model by inhibiting the Wnt/β-catenin signaling pathway. [Abstract]2024 Mar:136:102375. PMID: 38123002 -
Kidney Blood Press Res
Aberrant Gut Microbiome Contributes to Barrier Dysfunction, Inflammation and Local Immune Responses in IgA Nephropathy. [Abstract]2023;48(1):261-276. PMID: 36878203 -
Neurol Res
High-intensity interval training stimulates remyelination via the Wnt/β-catenin pathway in cuprizone-induced demyelination mouse model. [Abstract]2024 Jul 9:1-12. PMID: 38979727 -
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Solvent & Solubility
H2O : 50 mg/mL (Need ultrasonic)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL; Clear solution; Need ultrasonic
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Protocol
Samples are prepared in 96-well microplates and all wells without samples are filled with 200 μL PBS to minimize evaporation. To each well is loaded 100 μL SH-SY5Y growth medium with or without 10.000 SH-SY5Y neuroblastoma cells. The assay is started by adding 25 μL buffer, with or without 5 mg/mL sonicated Bovine Serum Albumin previously incubated for 0, 2 or 96 h at 70°C (giving a final BSA concentration of 1 mg/mL). All sample combinations are loaded in triplets, and for each of the six Bovine Serum Albumin combinations a corresponding triplet is loaded without cells, to be used as blank. One triplet is also loaded without both cells and BSA and one only without Bovine Serum Albumin[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Purity & Documentation
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Data Sheet (280 KB)
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SDS (557 KB)
- English - EN (557 KB)
- Français - FR (557 KB)
- Deutsch - DE (557 KB)
- Norwegian - NO (557 KB)
- Español - ES (557 KB)
- Swedish - SV (557 KB)
- Italian - IT (557 KB)
- Portuguese - PT (557 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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