Lars - leucyl-tRNA synthetase Gene

Also Known as Lars1; leuRS; 2310045K21Rik; 3110009L02Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 107045

Summary

Enables leucine-tRNA Ligase activity. Involved in leucyl-tRNA aminoacylation. Part of Aminoacyl-tRNA Synthetase multienzyme complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in infantile liver failure syndrome 1. Orthologous to human LARS1 (leucyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]

Lars Products (1)

mRNA Protein Name
NM_134137.3 NP_598898.2 leucine--tRNA ligase, cytoplasmic

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables leucine-tRNA ligase activity IMP
IMP: Inferred from mutant phenotype
12060739 MGI
Biological Process GO Annotation Evidence References Source
involved in leucyl-tRNA aminoacylation IDA
IDA: Inferred from direct assay
12060739 MGI
Cellular Component GO Annotation Evidence References Source
part of aminoacyl-tRNA synthetase multienzyme complex IDA
IDA: Inferred from direct assay
12060739 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

leucine--tRNA ligase, cytoplasmic

  • leucyl-tRNA synthetase, cytoplasmic

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-131180 BMS-986235 99.84% Phase 1

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-119019 ASB14780 Inhibitor 99.58% Unkown
HY-136242 UT-34 Degrader 98.09% Unkown
HY-105999 APC 366 Inhibitor 99.81% Unkown
HY-RS07532 LARS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21628 Lars2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-N12177 Cryptosporioptide A Inhibitor / Unkown
HY-RS07533 LARS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-N12776 Illudalic acid Inhibitor / Unkown
HY-RS17614 Ptprf Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21627 Lars1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28145 Lars1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28146 Lars2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown