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Cat. No.: HY-107128R

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Ampreloxetine hydrochloride (Standard)

(Synonyms: TD-9855 hydrochloride (Standard))

Ampreloxetine hydrochloride (Standard) (TD-9855 hydrochloride (Standard)) is the analytical standard of Ampreloxetine (hydrochloride) (HY-107128). This product is intended for research and analytical applications. Ampreloxetine (TD-9855) hydrochloride is an orally active and CNS-penetrant inhibitor of Norepinephrine transporter (NET) and Serotonin 5-HT uptake transporter (SERT), but not Dopamine transporter (DAT). Ampreloxetine hydrochloride binds norepinephrine transporters (NET) and serotonin transporters (SERT) with EC₅₀ values of 11.7 ng/mL and 50.8 ng/mL, respectively, in plasma.

For research use only. We do not sell to patients.

CAS No.: 1227056-87-2
Formula: C₁₈H₁₉ClF₃NO
Molecular Weight:357.80

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Please store the product under the recommended conditions in the Certificate of Analysis.

Ampreloxetine hydrochloride (Standard) Chemical Structure

CAS No.: 1227056-87-2

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Chemical Information

CAS No. 1227056-87-2
Molecular Weight 357.80
Formula C₁₈H₁₉ClF₃NO
SMILES

FC1=C(C(F)=CC(F)=C1)OCC2=C(C3CCNCC3)C=CC=C2.Cl
Synonyms

TD-9855 hydrochloride (Standard)
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Smith JA, et al. Preclinical to clinical translation of CNS transporter occupancy of TD-9855, a novel norepinephrine and serotonin reuptake inhibitor. Int J Neuropsychopharmacol. 2014 Dec 13;18(2):pyu027. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Ampreloxetine hydrochloride (Standard)

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Ampreloxetine hydrochloride (Standard)

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Ampreloxetine hydrochloride (Standard) Related Classifications

Cat. No.: HY-107128R