GFER - Gfer growth factor, augmenter of liver regeneration Gene

Also Known as ALR

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 27100

Summary

Enables flavin-linked sulfhydryl oxidase activity. Involved in several processes, including cellular response to actinomycin D; liver regeneration; and negative regulation of cell death. Located in cytosol; extracellular space; and mitochondrion. Used to study acute kidney failure. Biomarker of acute kidney failure; cryptorchidism; and ureteral obstruction. Human ortholog(s) of this gene implicated in kidney failure and renal fibrosis. Orthologous to human GFER (growth factor, augmenter of liver regeneration). [provided by Alliance of Genome Resources, Apr 2022]

GFER Products (1)

mRNA Protein Name
NM_013222.2 NP_037354.2 FAD-linked sulfhydryl oxidase ALR

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables flavin-dependent sulfhydryl oxidase activity IDA
IDA: Inferred from direct assay
11346147 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to actinomycin D IEP
IEP: Inferred from expression pattern
23073658 RGD
involved in cellular response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
23073658 RGD
involved in cellular response to toxic substance IEP
IEP: Inferred from expression pattern
23073658 RGD
involved in cellular response to tumor necrosis factor IEP
IEP: Inferred from expression pattern
23073658 RGD
involved in liver regeneration IMP
IMP: Inferred from mutant phenotype
24880092 RGD
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
18272248 RGD
involved in negative regulation of natural killer cell mediated cytotoxicity IDA
IDA: Inferred from direct assay
9021955 RGD
involved in positive regulation of DNA biosynthetic process IDA
IDA: Inferred from direct assay
16937468 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
23073658 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
10216127 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

FAD-linked sulfhydryl oxidase ALR

  • FAD-linked sulfhydryl oxidase ALR-like

  • augmenter of liver regeneration

  • growth factor, erv1 homolog

  • growth factor, erv1-like (augmenter of liver regeneration)

  • translation initiation factor IF-2-like

Recombinant GFER Proteins

Cat. No. Product Name Accession Purity
HY-P71571 GFER Protein, Rat (His-SUMO) Q63042 (M1-D198) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05377 GFER Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18362 Gfer Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24841 Gfer Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens GFER NCBI NCBI:2671