GFER - growth factor, augmenter of liver regeneration Gene

Also Known as ALR; HPO; HSS; ERV1; HPO1; HPO2; HERV1; MMCHD; MPMCD

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2671

About GFER

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:1,984,193-1,987,749 (from NCBI)

This gene has 5 transcripts (splice variants), 205 orthologues and is associated with 4 phenotypes. Ubiquitous expression in small intestine (RPKM 7.8), duodenum (RPKM 7.7) and 25 other tissues.

Summary

The hepatotrophic factor designated augmenter of liver regeneration (ALR) is thought to be one of the factors responsible for the extraordinary regenerative capacity of mammalian liver. It has also been called hepatic regenerative stimulation substance (HSS). The gene resides on chromosome 16 in the interval containing the locus for polycystic kidney disease (PKD1). The putative gene product is 42% similar to the scERV1 protein of yeast. The yeast scERV1 gene had been found to be essential for Oxidative Phosphorylation, the maintenance of mitochondrial genomes, and the cell division cycle. The human gene is both the structural and functional homolog of the yeast scERV1 gene. [provided by RefSeq, Jul 2008]

GFER Products (1)

mRNA	Protein	Name
NM_005262.3	NP_005253.3	FAD-linked sulfhydryl oxidase ALR

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables flavin adenine dinucleotide binding	IDA IDA: Inferred from direct assay	22224850	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12681488	GOA
enables protein-disulfide reductase activity	IDA IDA: Inferred from direct assay	22224850	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in mitochondrion	IDA IDA: Inferred from direct assay	23676665	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GFER Protein Structure

Evr1_Alr

0
100
205 a.a.

Protein Preferred Names	Protein Names
FAD-linked sulfhydryl oxidase ALR	ERV1 homolog

GFER Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	GFER	P55789	P0DTD1-PRO_0000449628	SARS-CoV-2	P0DTD1-PRO_0000449628	Y2H Array	36217030
Intra	GFER	P55789	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Prey Pooling	25416956
Intra	GFER	P55789	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant GFER Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70953	GFER Protein, Human (His)	P55789-2 (M1-D125)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P74126	GFER Protein, Human (HEK293, His, solution)	P55789-2 (M1-D125)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Myopathy, Mitochondrial Progressive, With Congenital Cataract And Developmental Delay	Myopathy, Mitochondrial Progressive, With Congenital Cataract, Hearing Loss, And Developmental Delay Congenital Cataract-Progressive Muscular Hypotonia-Hearing Loss-Developmental Delay Syndrome MPMCD Myopathy With Cataract And Combined Respiratory Chain Deficiency Mitochondrial Complex Deficiency, Combined Myopathy, Mitochondrial Progressive, With Congenital Cataract, Hearing Loss, And Myopathy With Cataract And Combined Respiratory-Chain Deficiency Congenital Cataract-Progressive Muscular Hypotonia-Deafness-Developmental Delay Syndrome Myopathy, Mitochondrial Progressive, With Congenital Cataract, Hearing Loss And Developmental Delay Combined Mitochondrial Complex Deficiency
Mitochondrial Disease	Mitochondrial Diseases Mitochondrial Disorder
Cataract	Cataracts Cat - [Cataract] Cataract Form Lens Opacity Lens Opacities
Myopathy	Muscular Diseases Myopathies
Budd-Chiari Syndrome	Hepatic Vein Thrombosis Chiari Syndrome BDCHS Membranous Obstruction Of The Inferior Vena Cava Budd-Chiari Syndrome, Somatic Movc Budd-Chiari Syndrome, Susceptibility To, Somatic Budd-Chiari Syndrome, Susceptibility To Membranous Obstruction Of Inferior Vena Cava Hepatic Vein Block Obstruction Of Hepatic Veins Hepatic Vein Obstruction Hepatic Venous Block
Sensorineural Hearing Loss	Sensory Hearing Loss Sensorineural Deafness Sensorineural Hearing Loss Disorder Hearing Loss, Sensorineural Central Hearing Loss High Frequency Deafness High Frequency Hearing Loss High-Frequency Hearing Loss Perceptive Deafness Perceptive Hearing Loss Perceptive Hearing Loss Or Deafness Hearing Loss Sensorineural Deafness Sensorineural Hearing Loss High-Frequency Hearing Loss, Central Hearing Loss, High-Frequency
Polycystic Kidney Disease	Polycystic Kidney Diseases Pkd Polycystic Renal Disease Kidney Disease, Polycystic Polycystic Kidney, Autosomal Dominant

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05377	GFER Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18362	Gfer Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24841	Gfer Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	GFER	VGNC	VGNC:62521
Rattus norvegicus	GFER	RGD	RGD:61845
Bos taurus	GFER	VGNC	VGNC:29324
Mus musculus	GFER	MGD	MGI:107757
Macaca mulatta	GFER	VGNC	VGNC:104729
Others	GFER	NCBI