17 Results for "

home

" in MedChemExpress (MCE) Product Catalog:
Products (17)

17 Results for "home" in MCE Product Catalog:

27
SKF-96365 (hydrochloride)
SKF-96365 (hydrochloride)
0 Images
27 Cited Publications
Cat. No.: HY-100001
CAS No.: 130495-35-1
Purity:  ≥99.01%
Target:  

TRP Channel CRAC Channel Autophagy CaMK Akt Apoptosis Na+/Ca2+ Exchanger Calcium Channel

Research Areas:  

Neurological Disease Inflammation/Immunology Cancer

SKF-96365 hydrochloride is a TRPC channel antagonist and store-operated calcium entry (SOCE) inhibitor. SKF-96365 hydrochloride reduces calcium ion influx by inhibiting the activity and expression of TRPC6, STIM1 and Orai1. SKF-96365 hydrochloride inhibits voltage-gated sodium current (cardiac INa/NaV1.5) and slows myocardial conduction. SKF-96365 hydrochloride inhibits phosphorylation/activation of CaMKIIγ and suppresses the downstream AKT signaling pathway. SKF-96365 hydrochloride induces G2/M phase cell cycle arrest, apoptosis and cytoprotective autophagy in colorectal cancer cells. SKF-96365 hydrochloride alleviates allergic rhinitis symptoms by reducing inflammatory cytokine levels. SKF-96365 hydrochloride reduces intracellular calcium overload, inhibits Homer1 expression, prevents nuclear damage and suppresses apoptosis. SKF-96365 hydrochloride inhibits the growth of colorectal cancer xenografts in nude mice . SKF-96365 hydrochloride is applicable to research related to allergic rhinitis, colorectal cancer, Parkinson's disease, persistent spontaneous nociception and hyperalgesia .
27
SKF-96365
SKF-96365
0 Images
27 Cited Publications
Cat. No.: HY-125942
CAS No.: 162849-90-3
Target:  

CRAC Channel TRP Channel CaMK Akt Apoptosis Autophagy Na+/Ca2+ Exchanger Calcium Channel

Research Areas:  

Neurological Disease Inflammation/Immunology Cancer

SKF-96365 is a TRPC channel antagonist and store-operated calcium entry (SOCE) inhibitor. SKF-96365 reduces calcium ion influx by inhibiting the activity and expression of TRPC6, STIM1 and Orai1. SKF-96365 inhibits voltage-gated sodium current (cardiac INa/NaV1.5) and slows myocardial conduction. SKF-96365 inhibits phosphorylation/activation of CaMKIIγ and suppresses the downstream AKT signaling pathway. SKF-96365 induces G2/M phase cell cycle arrest, apoptosis and cytoprotective autophagy in colorectal cancer cells. SKF-96365 alleviates allergic rhinitis symptoms by reducing inflammatory cytokine levels. SKF-96365 reduces intracellular calcium overload, inhibits Homer1 expression, prevents nuclear damage and suppresses apoptosis. SKF-96365 inhibits the growth of colorectal cancer xenografts in nude mice . SKF-96365 is applicable to research related to allergic rhinitis, colorectal cancer, Parkinson's disease, persistent spontaneous nociception and hyperalgesia .
CSTSMLKAC (disulfide)
CSTSMLKAC (disulfide)
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Cat. No.: HY-P5217
Target:  

Peptides

Research Areas:  

Others

CSTSMLKAC (peptide 2) is a cyclic 9 amino acid sequence that mimics endogenous peptide sequences. CSTSMLKAC homes to cardiomyocytes in the ischemic myocardium .
REA
REA
0 Images
Cat. No.: HY-P4089
CAS No.: 945245-82-9
Target:  

Peptides

Research Areas:  

Cancer

REA is a homing peptide that targets pre-cancerous tumor lymphatic vessels. REA homes to lymphatic vessels at the pre-cancerous tumor stage, but does not recognize tumor lymphatic vessels. REA can be used in pre-cancerous tumor research .
LyP-2
LyP-2
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Cat. No.: HY-P4088
CAS No.: 850859-24-4
Target:  

Peptides

Research Areas:  

Cancer

LyP-2 is a peptide that homes to tumor lymphatics. LyP2 homes to lymphatics of C8161 melanomas and cervical carcinomas and K14-HPV16 skin, but not to MDA-MB435 tumors, showing heterogeneity in the molecular markers of tumor cells and lymphatics .
Clorofene
Clorofene
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Cat. No.: HY-118547
CAS No.: 120-32-1
Synonyms: 2-Benzyl-4-chlorophenol
Target:  

Bacterial

Research Areas:  

Infection

Clorofene (2-Benzyl-4-chlorophenol) is an aryl halide fungicide widely used in hospitals and homes as a broad-spectrum fungicide in general cleaning and disinfection disinfectant solutions and in soap formulations. Clorofene has antibacterial and carcinogenic activity .
CES
CES
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Cat. No.: HY-P11029
Target:  

Peptides

Research Areas:  

Cancer

CES (CESPLLSEC) is a homing peptide targeting Synaptosomal associated protein 25 (SNAP25). CES specifically homes in intracranial U87MG and the WT-glioblastoma (GBM) model. CES can be used as a targeting peptide for drug delivery for cancers research .
Stroke-homing peptide
Stroke-homing peptide
0 Images
Cat. No.: HY-P11049
Target:  

Peptides

Research Areas:  

Neurological Disease

Stroke-homing peptide is a homing peptide. Stroke-homing peptide can home to ischemic stroke brain tissue and detect the apoptotic neuronal cells. Stroke-homing peptide can be used for the research of molecular imaging and selective drug delivery to stroke tissue .
HOMER1 Human Pre-designed siRNA Set A
HOMER1 Human Pre-designed siRNA Set A
Cat. No.: HY-RS06283
Target:  

Small Interfering RNA (siRNA)

Research Areas:  

Others

HOMER1 Human Pre-designed siRNA Set A contains three designed siRNAs for HOMER1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HOMER2 Human Pre-designed siRNA Set A
HOMER2 Human Pre-designed siRNA Set A
Cat. No.: HY-RS06284
Target:  

Small Interfering RNA (siRNA)

Research Areas:  

Others

HOMER2 Human Pre-designed siRNA Set A contains three designed siRNAs for HOMER2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HOMER3 Human Pre-designed siRNA Set A
HOMER3 Human Pre-designed siRNA Set A
Cat. No.: HY-RS06285
Target:  

Small Interfering RNA (siRNA)

Research Areas:  

Others

HOMER3 Human Pre-designed siRNA Set A contains three designed siRNAs for HOMER3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Homer1 Mouse Pre-designed siRNA Set A
Homer1 Mouse Pre-designed siRNA Set A
Cat. No.: HY-RS21139
Target:  

Small Interfering RNA (siRNA)

Research Areas:  

Others

Homer1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Homer1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

10(S)-HOME
10(S)-HOME
0 Images
Cat. No.: HY-145511
CAS No.: 263023-34-3
Target:  

Drug Intermediate

Research Areas:  

Metabolic Disease

10(S)-HOME is an oxylipin.
Homer1 Rat Pre-designed siRNA Set A
Homer1 Rat Pre-designed siRNA Set A
Cat. No.: HY-RS27657
Target:  

Small Interfering RNA (siRNA)

Research Areas:  

Others

Homer1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Homer1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Anti-Mouse CXCR4 Antibody (Cx4Mab-1)
Anti-Mouse CXCR4 Antibody (Cx4Mab-1)
0 Images
Cat. No.: HY-P991744

Target:  

CXCR

Research Areas:  

Cancer

Anti-Mouse CXCR4 Antibody is a monoclonal antibody that specifically recognizes murine CXCR4 (C-X-C chemokine receptor 4), also known as fusin or CD184. CXCR4 is a seven-transmembrane G protein–coupled receptor whose principal endogenous ligand is CXCL12 (stromal cell–derived factor-1α, SDF-1α) and is widely expressed in hematopoietic cells, endothelial cells, neurons, as well as embryonic and adult stem cells. The CXCR4–CXCL12 signaling axis activates multiple downstream pathways, including ERK1/2, Ras, p38 MAPK, PLC/MAPK, and SAPK/JNK, thereby regulating cell survival, proliferation, migration, and stemness maintenance. Aberrant overexpression of CXCR4 is closely associated with poor prognosis and metastasis in various cancers, with CXCR4-positive tumor cells preferentially home to CXCL12-rich tissues such as the liver, bone marrow, lung, and lymph nodes. Accordingly, CXCR4 and its CXCL12-related antagonists emerge as attractive targets for experimental anticancer therapy. Anti-Mouse CXCR4 Antibody is generated using a cell-based immunization and screening strategy and exhibits high affinity for both endogenous and exogenous murine CXCR4. Anti-Mouse CXCR4 Antibody can be used for thestudy of chronic lymphocytic leukemia and multiple myeloma .
Homer1 Protein, Human (His)
Homer1 Protein, Human (His)
0 Images
Cat. No.: HY-P705527
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: home1_HUMAN; homer ; homeR 1A; homeR 1B ; homeR 1C; homer homolog 1 (Drosophila); homer homolog 1; homer protein homolog 1; homer scaffolding protein 1; homer; Drosophila; homolog of; 1; homer; neuronal immediate early gene; 1 ; homer-1; homer1; homeR1A; homeR1B; homeR1C; SYN47 ; Ves 1
Species:  
Human
Source:  
E. coli
Homer1 Antibody (YA6602)
Homer1 Antibody (YA6602)
0 Images
Cat. No.: HY-P86909
Synonyms: home1_HUMAN antibody; homer antibody; homeR 1A antibody; homeR 1B antibody; homeR 1C antibody; homer homolog 1 (Drosophila) antibody; homer homolog 1 antibody; homer protein homolog 1 antibody; homer scaffolding protein 1 antibody; homer, Drosophila, homolog of, 1 antibody; home1_HUMAN antibody; homer antibody; homeR 1A antibody; homeR 1B antibody; homeR 1C antibody; homer homolog 1 (Drosophila) antibody; homer homolog 1 antibody; homer protein homolog 1 antibody; homer scaffolding protein 1 antibody; homer, Drosophila, homolog of, 1 antibody; homer, neuronal immediate early gene, 1 antibody; homer-1 antibody; homer1 antibody; homeR1A antibody; homeR1B antibody; homeR1C antibody; SYN47 antibody; Ves 1 antibody;

Host:  

Rabbit

Application:  

WB, IHC-P, IHC-F

Reactivity:  

Mouse, Rat

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Assay Types