3106963-85-0
Chemical Structure
JAK1-IN-20
- CAS No.: 3106963-85-0
- Formula:C26H25ClFN7O3
- Molecular Weight:537.97
InChIKey: ZKUSRDKVIYERQX-UHFFFAOYSA-N
SMILES: ClC1=CN=C(N=C1NC2CCN(CC2)C(NC3=CC=C(C=C3F)C(C)=O)=O)NC4=CC(CN5)=C(C=C4)C5=O
Biological Activity: JAK1-IN-20 (Compound 38) is a gut-restricted, orally active, selective JAK1 inhibitor with an IC50 of <0.5 nM. JAK1-IN-20 inhibits the enzymatic activity of JAK1, reduces the production of proinflammatory cytokines (TNF-α, IL-6), and suppresses the phosphorylation of STAT3. JAK1-IN-20 ameliorates ulcerative colitis. JAK1-IN-20 can be used for the research of inflammatory bowel disease[1].
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JAK1-IN-20 | JAK1-IN-20 (Compound 38) is a gut-restricted, orally active, selective JAK1 inhibitor with an IC50 of <0.5 nM. JAK1-IN-20 inhibits the enzymatic activity of JAK1, reduces the production of proinflammatory cytokines (TNF-α, IL-6), and suppresses the phosphorylation of STAT3. JAK1-IN-20 ameliorates ulcerative colitis. JAK1-IN-20 can be used for the research of inflammatory bowel disease. | |||||||||||||||||||||
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Keywords
