Nelremagpran
Based on 1 Customer Validation
MRGPRX4 modulator-2 (compound 1-55) is a potent MRGPR X4 modulator, possessing antagonist activity against MRGPR X4 with an IC50 < 100 nM. MRGPRX4 modulator-2 can be used for researching autoimmune diseases such as psoriasis, multiple sclerosis, Steven Johnson’s Syndrome, and other chronic itch conditions.
For research use only. We do not sell to patients.
- Purity: 99.94%
- CAS No.: 2492595-24-9
- Formula: C15H9ClF4O3
- Molecular Weight:348.68
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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GPCR/G Protein Compound Library
HY-L006
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Immunology/Inflammation Compound Library
HY-L007
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Membrane Protein-targeted Compound Library
HY-L149
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Membrane Receptor-targeted Compound Library
HY-L150
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
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Lactylation Compound Library
HY-L249
Biological Activity
IC50: < 100 nM (MRGPR X4)[1]
Chemical Information
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CAS No. 2492595-24-9
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Appearance Solid
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Molecular Weight 348.68
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Formula C15H9ClF4O3
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Color White to off-white
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SMILES
O=C(O)C1=CC=CC(COC2=CC=C(C(F)(F)F)C=C2Cl)=C1F
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Synonyms
MRGPRX4 modulator-2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (143.40 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Purity & Documentation
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Data Sheet (269 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8680 mL | 14.3398 mL | 28.6796 mL | 71.6990 mL |
| 5 mM | 0.5736 mL | 2.8680 mL | 5.7359 mL | 14.3398 mL | |
| 10 mM | 0.2868 mL | 1.4340 mL | 2.8680 mL | 7.1699 mL | |
| 15 mM | 0.1912 mL | 0.9560 mL | 1.9120 mL | 4.7799 mL | |
| 20 mM | 0.1434 mL | 0.7170 mL | 1.4340 mL | 3.5849 mL | |
| 25 mM | 0.1147 mL | 0.5736 mL | 1.1472 mL | 2.8680 mL | |
| 30 mM | 0.0956 mL | 0.4780 mL | 0.9560 mL | 2.3900 mL | |
| 40 mM | 0.0717 mL | 0.3585 mL | 0.7170 mL | 1.7925 mL | |
| 50 mM | 0.0574 mL | 0.2868 mL | 0.5736 mL | 1.4340 mL | |
| 60 mM | 0.0478 mL | 0.2390 mL | 0.4780 mL | 1.1950 mL | |
| 80 mM | 0.0358 mL | 0.1792 mL | 0.3585 mL | 0.8962 mL | |
| 100 mM | 0.0287 mL | 0.1434 mL | 0.2868 mL | 0.7170 mL |
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