2,4,6-Triiodophenol
Based on 1 Customer Validation
2,4,6-Triiodophenol is an orally active and potent leukotriene B4 (LTB4) synthesis inhibitor. 2,4,6-Triiodophenol can induce mouse blastocysts apoptosis.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 98.0%
- No. CAS: 609-23-4
- Fòrmula: C6H3I3O
- Peso molecular:471.80
-
Almacenamiento:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
-
Solvente y solubilidad
- Pureza y Documentación
- Referencias
-
Help & FAQs
-
Apoptosis Compound Library
HY-L003
-
Anti-Aging Compound Library
HY-L034
-
Oxygen Sensing Compound Library
HY-L045
-
Orally Active Compound Library
HY-L061
-
Cell Death Library
HY-L162
-
Bioactive Compound Library Max
HY-L181
-
MCE Bioactive Compound Library
HY-L001V
-
Bioactive Compound Library
HY-L001
-
Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
-
High-Throughput Bioactive Compound Library
HY-L205
Actividad biológica
2,4,6-Triiodophenol (5-50 μM; 0-100 h) impairs the quality of pre-implantation mouse embryos in a dose-dependent manner, inducing decline of both total and trophectoderm cell numbers[2].
2,4,6-Triiodophenol (5 μM; 85 h) shows increasement of apoptotic cells in mouse pre-implantation embryos[2].
2,4,6-Triiodophenol (5-50 μM; 100 h) induces oxidative stress in mouse pre-implantation embryos[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:Mouse blastocyst cells
-
Concentration:5 μM
-
Incubation Time:85 hours
-
Result:Showed signals of activated Caspase-3/7.
-
Cell Line:Mouse blastocyst cells
-
Concentration:5-50 μM
-
Incubation Time:100 hours
-
Result:Resulted in marked increase of oxygen species (ROS) treated with high dose of 2,4,6-Triiodophenol.
Chemical Information
-
No. CAS 609-23-4
-
Appearance Solid
-
Peso molecular 471.80
-
Fòrmula C6H3I3O
-
Color Off-white to pink
-
SMILES
OC1=C(I)C=C(I)C=C1I
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvente y solubilidad
DMSO : 250 mg/mL (529.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
-
Ficha de datos (273 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Instrucciones de manejo (2659 KB)
Referencias
[1]. Liu S, et al. 2,4,6-triiodophenol exhibits embryotoxicity to pre-implantation mouse embryos in an in vitro exposure model. Ecotoxicol Environ Saf. 2022 Aug;241:113745. [Content Brief]
[2]. Trocóniz IF, et al. Dealing with time-dependent pharmacokinetics during the early clinical development of a new leukotriene B4 synthesis inhibitor. Pharm Res. 2006 Jul;23(7):1533-42. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1195 mL | 10.5977 mL | 21.1954 mL | 52.9886 mL |
| 5 mM | 0.4239 mL | 2.1195 mL | 4.2391 mL | 10.5977 mL | |
| 10 mM | 0.2120 mL | 1.0598 mL | 2.1195 mL | 5.2989 mL | |
| 15 mM | 0.1413 mL | 0.7065 mL | 1.4130 mL | 3.5326 mL | |
| 20 mM | 0.1060 mL | 0.5299 mL | 1.0598 mL | 2.6494 mL | |
| 25 mM | 0.0848 mL | 0.4239 mL | 0.8478 mL | 2.1195 mL | |
| 30 mM | 0.0707 mL | 0.3533 mL | 0.7065 mL | 1.7663 mL | |
| 40 mM | 0.0530 mL | 0.2649 mL | 0.5299 mL | 1.3247 mL | |
| 50 mM | 0.0424 mL | 0.2120 mL | 0.4239 mL | 1.0598 mL | |
| 60 mM | 0.0353 mL | 0.1766 mL | 0.3533 mL | 0.8831 mL | |
| 80 mM | 0.0265 mL | 0.1325 mL | 0.2649 mL | 0.6624 mL | |
| 100 mM | 0.0212 mL | 0.1060 mL | 0.2120 mL | 0.5299 mL |
2,4,6-Triiodophenol Related Classifications
HY-W073687 Related Classifications
Powered by Bioz