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Referencia número: HY-161021

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AC2 selective-IN-1

AC2 selective-IN-1 (compound 14) is a? potent (IC₅₀=4.45 μM), non-toxic, and selective mAC2 inhibitor.

Para uso exclusivo en investigación. No vendemos a pacientes.

Fòrmula: C₄₁H₄₇N₈O₈P
Peso molecular:810.83

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

AC2 selective-IN-1 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Cellular Effect
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

AC2 selective-IN-1 (compound 14) is a? potent (IC₅₀=4.45 μM), non-toxic, and selective mAC2 inhibitor^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
CCRF-CEM	IC₅₀	>10 μM Compound: 14	Cytotoxicity against human CCRF-CEM cells by CellTiter-Glo 2.0 assay Cytotoxicity against human CCRF-CEM cells by CellTiter-Glo 2.0 assay	[PMID: 37931521]
HeLa S3	IC₅₀	>10 μM Compound: 14	Cytotoxicity against human HeLa S3 cells by CellTiter-Glo 2.0 assay Cytotoxicity against human HeLa S3 cells by CellTiter-Glo 2.0 assay	[PMID: 37931521]
HepG2	IC₅₀	>10 μM Compound: 14	Cytotoxicity against human HepG2 cells by CellTiter-Glo 2.0 assay Cytotoxicity against human HepG2 cells by CellTiter-Glo 2.0 assay	[PMID: 37931521]
HL-60	IC₅₀	10 μM Compound: 14	Cytotoxicity against human HL-60 cells by CellTiter-Glo 2.0 assay Cytotoxicity against human HL-60 cells by CellTiter-Glo 2.0 assay	[PMID: 37931521]
NHDF	IC₅₀	>10 μM Compound: 14	Cytotoxicity against human NHDF cells by CellTiter-Glo 2.0 assay Cytotoxicity against human NHDF cells by CellTiter-Glo 2.0 assay	[PMID: 37931521]

Chemical Information

Peso molecular 810.83
Fòrmula C₄₁H₄₇N₈O₈P
SMILES

NC1=C2C(N(CCOCP(N[C@H](C(OC(C)C)=O)CC3=CC=CC=C3)(N[C@@H](CC4=CC=CC=C4)C(OC(C)C)=O)=O)C=C2C5=CC=CC(C(N6)=NOC6=O)=C5)=NC=N1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Pavel Kraina, et al. Discovery of a potent and selective human AC2 inhibitor based on 7-deazapurine analogues of adefovir. Bioorg Med Chem. 2023. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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