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Referencia número: HY-182272

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FAP-IN-9

FAP-IN-9 (compound P12) is a fibroblast activation protein (FAP) inhibitor with an IC₅₀ of 0.38 nM against human FAP. FAP-IN-9 functionally inhibits FAP activity, and its specific binding is verified by in vitro and in vivo blocking assays. FAP-IN-9 forms stable complexes and acts as a tumor-targeting agent. When labeled with ^99mTc, FAP-IN-9 serves as a SPECT probe and is applicable to research related to glioblastoma.

Para uso exclusivo en investigación. No vendemos a pacientes.

Fòrmula: C₅₇H₇₆F₂N₉NaO₁₉S
Peso molecular:1284.31

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

FAP-IN-9 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- In Vitro
- In Vivo
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

In Vitro

FAP-IN-9 (P12) (4 pM-40 μM; 30 min (37 °C)) exhibits high binding affinity for recombinant human FAP protein, with an IC₅₀ of 0.38 nM^[1].
^99mTc-TE-FAP-IN-9 and ^99mTc-TT-FAP-IN-9 exhibit moderate hydrophilicity, with LogP values of -2.78 and -3.27, respectively^[1].
^99mTc-TE-FAP-IN-9 and ^99mTc-TT-FAP-IN-9 (37 MBq; 6 h (PBS, room temp); 6 h (human blood serum, 37 °C)) demonstrate excellent in vitro stability, with radiochemical purity remaining above 95% after 6 h of incubation in PBS at room temperature or human blood serum at 37 °C^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

^99mTc-TE-P12 and ^99mTc-TT-P12, derivatives of FAP-IN-9 (P12) (3.7 MBq; i.v.; single dose), exhibit high, FAP-specific tumor uptake in U87MG glioblastoma-bearing mice, with ^99mTc-TT-P12 showing the highest tumor uptake (44.86 %ID/g at 60 minutes p.i.) and sustained retention over 4 hours, while both agents achieve high tumor-to-nontarget tissue ratios suitable for SPECT imaging^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Peso molecular 1284.31
Fòrmula C₅₇H₇₆F₂N₉NaO₁₉S
SMILES

O=C(NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(NC1=CC=CC2=C1N=CC=C2C(NCC(N3CC(C[C@@H]3C#N)(F)F)=O)=O)=O)C4=CC=C(N/N=C/C5=C(S(=O)(O[Na])=O)C=CC=C5)N=C4
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Sufan Tang, et al. Synthesis
and In Vivo and In Vitro Properties
of ^99mTc-Labeled Fibroblast
Activation Protein Inhibitors. Mol. Pharmaceutics 2026, 23, 2752−2765.

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

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Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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