GRM4 - glutamate metabotropic receptor 4 Gene
Also Known as mGlu4; GPRC1D; MGLUR4
Species: Homo sapiens
About GRM4
This gene has 14 transcripts (splice variants), 271 orthologues and 7 paralogues. Low expression observed in reference dataset.
Summary
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and Metabotropic Glutamate Receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The Metabotropic Glutamate Receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate Phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
GRM4 Products (8)
| mRNA | Protein | Name |
|---|---|---|
| NM_001256810.1 | ||
| NM_001256814.1 | ||
| NM_001256811.3 | NP_001243740.1 | metabotropic glutamate receptor 4 isoform 4 precursor |
| NM_001256813.3 | NP_001243742.1 | metabotropic glutamate receptor 4 isoform 6 |
| NM_001256812.2 | NP_001243741.1 | metabotropic glutamate receptor 4 isoform 5 |
| NM_001282847.2 | NP_001269776.1 | metabotropic glutamate receptor 4 isoform 8 |
| NM_000841.4 | NP_000832.1 | metabotropic glutamate receptor 4 isoform 1 precursor |
| NM_001256809.3 | NP_001243738.1 | metabotropic glutamate receptor 4 isoform 2 |
| Molecular Function GO Annotation | Evidence | Referencias | Source |
|---|---|---|---|
| enables G protein-coupled receptor activity |
IMP
IMP: Inferred from mutant phenotype
|
8738157 | GOA |
| enables glutamate receptor activity |
IMP
IMP: Inferred from mutant phenotype
|
8738157 | GOA |
| Biological Process GO Annotation | Evidence | Referencias | Source |
|---|---|---|---|
| involved in adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway |
IMP
IMP: Inferred from mutant phenotype
|
15102938 | GOA |
| involved in positive regulation of MAPK cascade |
IDA
IDA: Inferred from direct assay
|
15102938 | GOA |
| Cellular Component GO Annotation | Evidence | Referencias | Source |
|---|---|---|---|
| located in cytoplasmic vesicle |
IDA
IDA: Inferred from direct assay
|
15102938 | GOA |
| located in plasma membrane |
IDA
IDA: Inferred from direct assay
|
15102938 | GOA |
GRM4 Protein Structure
ANF_receptor: Receptor family ligand binding region (78 - 481)
NCD3G: Nine Cysteines Domain of family 3 GPCR (516 - 566)
7tm_3: 7 transmembrane sweet-taste receptor of 3 GCPR (597 - 845)
- 0
- 200
- 400
- 600
- 800
- 912 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
metabotropic glutamate receptor 4 |
|
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Childhood Absence Epilepsy |
|
|
| Schizophrenia |
|
|
| Epilepsy, Myoclonic Juvenile |
|
|
| Epilepsy |
|
|
Related Agents
- Pre-clinical Phase
Pre-clinical Phase
| Referencia número | Nombre del producto |
Efecto
|
Pureza |
Rare Diseases
|
|---|---|---|---|---|
| HY-15476 | VU 0364439 | 99.42% | Unkown | |
| HY-RS05828 | GRM4 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS05829 | Grm4 Mouse Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS05830 | Grm4 Rat Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
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