RGL2 - ral guanine nucleotide dissociation stimulator like 2 Gene

Also Known as KE1.5; RAB2L; HKE1.5

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5863

About RGL2

Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38): 6:33,291,654-33,301,612 (from NCBI)

This gene has 11 transcripts (splice variants), 1 gene allele, 100 orthologues and 24 paralogues. Ubiquitous expression in spleen (RPKM 40.1), prostate (RPKM 26.5) and 25 other tissues.

Summary

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of catalytic activity and small GTPase mediated signal transduction. Predicted to act upstream of or within negative regulation of cardiac muscle cell apoptotic process; positive regulation of phosphatidylinositol 3-kinase signaling; and regulation of Ral protein signal transduction. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

RGL2 Products (2)

mRNA	Protein	Name
NM_001243738.2	NP_001230667.1	ral guanine nucleotide dissociation stimulator-like 2 isoform 2
NM_004761.5	NP_004752.1	ral guanine nucleotide dissociation stimulator-like 2 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Referencias	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20936779	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RGL2 Protein Structure

RasGEF_N

0
100
146 a.a.

Protein Preferred Names	Protein Names
ral guanine nucleotide dissociation stimulator-like 2	GDS-related protein

RGL2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Referencias
Intra	RGL2	O15211	KRTAP10-8	Homo sapiens	P60410	Validated Y2H	32296183
Intra	RGL2	O15211	KRTAP10-8	Homo sapiens	P60410	Y2H Array	32296183
Intra	RGL2	O15211	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	32296183
Intra	RGL2	O15211	ADAMTSL4	Homo sapiens	Q6UY14-3	Validated Y2H	32296183
Intra	RGL2	O15211	ADAMTSL4	Homo sapiens	Q6UY14-3	Y2H Array	32296183
Intra	RGL2	O15211	ADAMTSL4	Homo sapiens	Q6UY14-3	Y2H Prey Pooling	32296183
Intra	RGL2	O15211	KPRP	Homo sapiens	Q5T749	Y2H Array	32296183
Intra	RGL2	O15211	KPRP	Homo sapiens	Q5T749	Y2H Prey Pooling	32296183
Intra	RGL2	O15211	KPRP	Homo sapiens	Q5T749	Validated Y2H	32296183
Intra	RGL2	O15211	HRAS	Homo sapiens	P01112	Y2H Pooling	20936779
Intra	RGL2	O15211	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	RGL2	O15211	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	RGL2	O15211	GORASP2	Homo sapiens	Q9H8Y8	Validated Y2H	32296183
Intra	RGL2	O15211	GORASP2	Homo sapiens	Q9H8Y8	Y2H Array	32296183
Intra	RGL2	O15211	GORASP2	Homo sapiens	Q9H8Y8	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Tumoral Calcinosis, Normophosphatemic, Familial	Normophosphatemic Familial Tumoral Calcinosis NFTC Tumoral Calcinosis, Familial, Normophosphatemic Calcinosis, Tumoral, With Normophosphatemia Familial Normophosphatemic Tumoral Calcinosis Tumoral Calcinosis With Normophosphatemia
Calcinosis	Pathologic Calcification Pathologically Calcified Structure

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-RS11891	RGL2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21420	Rgl2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	RGL2	VGNC	VGNC:76886
Bos taurus	RGL2	VGNC	VGNC:33904
Rattus norvegicus	RGL2	RGD	RGD:1302985
Canis familiaris	RGL2	VGNC	VGNC:45513
Mus musculus	RGL2	MGD	MGI:107483
Others	RGL2	NCBI