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LO-4-25

LO-4-25 is a covalent degrader targeting the androgen receptor (AR) and its truncated variant AR-V7. LO-4-25 covalently binds to the E3 ubiquitin ligase CUL4 DCAF16, promoting the ubiquitination of AR and AR-V7, which subsequently are recognized and degraded by the proteasome, reducing the protein levels of AR and AR-V7 in cells. LO-4-25 is promising for research of androgen-independent prostate cancers.

Para uso exclusivo en investigación. No vendemos a pacientes.

  • Fòrmula: C32H37ClN6O5S
  • Peso molecular:653.19
  • Almacenamiento:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • LO-4-25 Chemical Structure
    LO-4-25 Chemical Structure
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Encuentre su distribuidor local Your local distributor: Hycultec GmbHHycultec
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  • LO-4-25 Chemical Structure
    LO-4-25 Chemical Structure
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  • LO-4-25