QO 58
Based on 1 Customer Validation
QO 58 is a potent modulator of K(v)7 channels. QO-58 increases the current amplitudes, shifts the voltage-dependent activation curve in a more negative direction and slows the deactivation of K(v)7.2/K(v)7.3 currents. QO-58 has the potential for the research of diseases associated with neuronal hyperexcitability.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.01%
- No. CAS: 1259536-62-3
- Fòrmula: C18H8Cl2F4N4O
- Peso molecular:443.18
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Membrane Transporter/Ion Channel Compound Library
HY-L011
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Heterocyclic Compound Library
HY-L138
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Membrane Protein-targeted Compound Library
HY-L149
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Membrane Receptor-targeted Compound Library
HY-L150
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Ion Channel Compound Library
HY-L166
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HY-L181
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MCE Bioactive Compound Library
HY-L001V
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High-Throughput Bioactive Compound Library
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | EC50 |
0.06 μM
Compound: 17
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Activation of KCNQ2/Q3 expressed in CHO cells by atomic absorption Rb'+ efflux assay
Activation of KCNQ2/Q3 expressed in CHO cells by atomic absorption Rb'+ efflux assay
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[PMID: 21296466] |
| HEK293 | EC50 |
49.29 μM
Compound: 17
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Activation of KCNQ1 expressed in HEK293 cells by atomic absorption Rb'+ efflux assay
Activation of KCNQ1 expressed in HEK293 cells by atomic absorption Rb'+ efflux assay
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[PMID: 21296466] |
Chemical Information
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No. CAS 1259536-62-3
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Appearance Solid
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Peso molecular 443.18
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Fòrmula C18H8Cl2F4N4O
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Color White to off-white
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SMILES
O=C1C=C(C2=C(Cl)N=C(Cl)C(F)=C2)NC3=C(C(C(F)(F)F)=NN13)C4=CC=CC=C4
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : ≥ 62.5 mg/mL (141.03 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2564 mL | 11.2821 mL | 22.5642 mL | 56.4105 mL |
| 5 mM | 0.4513 mL | 2.2564 mL | 4.5128 mL | 11.2821 mL | |
| 10 mM | 0.2256 mL | 1.1282 mL | 2.2564 mL | 5.6410 mL | |
| 15 mM | 0.1504 mL | 0.7521 mL | 1.5043 mL | 3.7607 mL | |
| 20 mM | 0.1128 mL | 0.5641 mL | 1.1282 mL | 2.8205 mL | |
| 25 mM | 0.0903 mL | 0.4513 mL | 0.9026 mL | 2.2564 mL | |
| 30 mM | 0.0752 mL | 0.3761 mL | 0.7521 mL | 1.8803 mL | |
| 40 mM | 0.0564 mL | 0.2821 mL | 0.5641 mL | 1.4103 mL | |
| 50 mM | 0.0451 mL | 0.2256 mL | 0.4513 mL | 1.1282 mL | |
| 60 mM | 0.0376 mL | 0.1880 mL | 0.3761 mL | 0.9402 mL | |
| 80 mM | 0.0282 mL | 0.1410 mL | 0.2821 mL | 0.7051 mL | |
| 100 mM | 0.0226 mL | 0.1128 mL | 0.2256 mL | 0.5641 mL |
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