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Referencia número: HY-156349

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Sec61-IN-4

Sec61-IN-4 (Compound 16b) is a Sec61 inhibitor (IC₅₀: 0.04 nM in U87-MG cells).

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Fòrmula: C₆₅H₁₁₁N₁₁O₁₅
Peso molecular:1286.64

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Sec61-IN-4 Chemical Structure

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Actividad biológica
- Descripciòn
- Cellular Effect
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

Sec61-IN-4 (Compound 16b) is a Sec61 inhibitor (IC₅₀: 0.04 nM in U87-MG cells)^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	CC₅₀	1.3 nM Compound: 16b	Cytotoxicity against human A549 cells assessed as decrease in cell viability incubated for 72 hrs by MTS assay Cytotoxicity against human A549 cells assessed as decrease in cell viability incubated for 72 hrs by MTS assay	[PMID: 37849553]
HCT-116	CC₅₀	3.4 nM Compound: 16b	Cytotoxicity against human HCT-116 cells assessed as decrease in cell viability incubated for 72 hrs by CellTiter-Glo Luminescent Cell Viability Assay Cytotoxicity against human HCT-116 cells assessed as decrease in cell viability incubated for 72 hrs by CellTiter-Glo Luminescent Cell Viability Assay	[PMID: 37849553]
NHDF	CC₅₀	3.9 nM Compound: 16b	Cytotoxicity against HDF cells assessed as decrease in cell viability incubated for 72 hrs by CellTiter-Glo Luminescent Cell Viability Assay Cytotoxicity against HDF cells assessed as decrease in cell viability incubated for 72 hrs by CellTiter-Glo Luminescent Cell Viability Assay	[PMID: 37849553]
U-87MG ATCC	CC₅₀	2.2 nM Compound: 16b	Cytotoxicity against human U87 cells assessed as decrease in cell viability incubated for 72 hrs by CellTiter-Glo Luminescent Cell Viability Assay Cytotoxicity against human U87 cells assessed as decrease in cell viability incubated for 72 hrs by CellTiter-Glo Luminescent Cell Viability Assay	[PMID: 37849553]
U-87MG ATCC	IC₅₀	0.04 nM Compound: 16b	Antiproliferative activity against human U-87 MG cells expressing GLuc assessed as as inhibition of GLuc secretion incubated for 18 hrs by CellTiter-Glo Luminescent Cell Viability Assay Antiproliferative activity against human U-87 MG cells expressing GLuc assessed as as inhibition of GLuc secretion incubated for 18 hrs by CellTiter-Glo Luminescent Cell Viability Assay	[PMID: 37849553]

Chemical Information

Peso molecular 1286.64
Fòrmula C₆₅H₁₁₁N₁₁O₁₅
SMILES

CN(C)[C@H](C(O[C@@H](C(N([C@H](C(N(C)[C@@H](CC(C)C)C(N(C)[C@H](C(N(C)[C@H](C(N(C)[C@@H]([C@@H](C)CC)C(N[C@H](C(N(C)[C@H](C(N[C@H](C1=O)CC2=CC=C(C=C2)OC)=O)CC(C)C)=O)C)=O)=O)COC)=O)[C@H](NC([C@@H](C)N1C)=O)C)=O)=O)COC)C)=O)C(C)C)=O)C(C)C
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Suzuki R, et al. Design of Synthetic Surrogates for the Macrolactone Linker Motif in Coibamide A. ACS Med Chem Lett. 2023 Sep 19;14(10):1344-1350. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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