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MRAP2 - melanocortin 2 receptor accessory protein 2 Gene

Also Known as C6orf117; bA51G5.2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 112609

About MRAP2

Cytogenetic location: 6q14.2 Genomic coordinates (GRCh38): 6:84,033,178-84,146,282 (from NCBI)

This gene has 1 transcript (splice variant), 153 orthologues and is associated with 1 phenotype. Broad expression in brain (RPKM 4.0), adrenal (RPKM 2.1) and 20 other tissues.

Summary

This gene encodes a protein that modulates Melanocortin Receptor signaling. The encoded protein has been shown to interact with all known melanocortin receptors and may regulate both receptor trafficking and activation in response to ligands. Mice lacking a functional copy of this gene exhibit severe obesity and a mutation in this gene may be associated with severe obesity in human patients. [provided by RefSeq, Oct 2016]

MRAP2 Products (5)

mRNA	Protein	Name
NM_001346541.2	NP_001333470.1	melanocortin-2 receptor accessory protein 2 isoform 2
NM_001346542.2	NP_001333471.1	melanocortin-2 receptor accessory protein 2 isoform 1
NM_001346543.2	NP_001333472.1	melanocortin-2 receptor accessory protein 2 isoform 3
NM_001346544.2	NP_001333473.1	melanocortin-2 receptor accessory protein 2 isoform 1
NM_138409.4	NP_612418.2	melanocortin-2 receptor accessory protein 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables corticotropin hormone receptor binding	IPI IPI: Inferred from physical interaction	19329486	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	19329486	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19329486	GOA
enables type 1 melanocortin receptor binding	IPI IPI: Inferred from physical interaction	19329486	GOA
enables type 3 melanocortin receptor binding	IPI IPI: Inferred from physical interaction	19329486	GOA
enables type 4 melanocortin receptor binding	IPI IPI: Inferred from physical interaction	19329486	GOA
enables type 5 melanocortin receptor binding	IPI IPI: Inferred from physical interaction	19329486	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	19329486	GOA
involved in negative regulation of protein localization to plasma membrane	IDA IDA: Inferred from direct assay	19329486	GOA
involved in positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	19329486	GOA
involved in protein localization to plasma membrane	IDA IDA: Inferred from direct assay	19329486	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	19329486	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	19329486	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MRAP2 Protein Structure

MRAP

0
100
205 a.a.

Protein Preferred Names	Protein Names
melanocortin-2 receptor accessory protein 2	MC2R accessory protein 2

MRAP2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MRAP2	Q96G30	TMEM80	Homo sapiens	Q96HE8	Y2H Prey Pooling	32296183
Intra	MRAP2	Q96G30	TMEM80	Homo sapiens	Q96HE8	Validated Y2H	32296183
Intra	MRAP2	Q96G30	TMEM80	Homo sapiens	Q96HE8	Y2H Array	32296183
Intra	MRAP2	Q96G30	BDNF	Homo sapiens	P23560-2	Y2H Pooling	32814053
Intra	MRAP2	Q96G30	BDNF	Homo sapiens	P23560-2	Validated Y2H	32814053
Intra	MRAP2	Q96G30	BDNF	Homo sapiens	P23560-2	Y2H Array	32814053
Intra	MRAP2	Q96G30	ISLR2	Homo sapiens	Q6UXK2	Y2H Array	32296183
Intra	MRAP2	Q96G30	ISLR2	Homo sapiens	Q6UXK2	Y2H Prey Pooling	32296183
Intra	MRAP2	Q96G30	APH1A	Homo sapiens	Q96BI3	Y2H Prey Pooling	32296183
Intra	MRAP2	Q96G30	APH1A	Homo sapiens	Q96BI3	Y2H Array	32296183
Intra	MRAP2	Q96G30	SGTA	Homo sapiens	O43765	Y2H Prey Pooling	32296183
Intra	MRAP2	Q96G30	SGTA	Homo sapiens	O43765	Y2H Array	32296183
Intra	MRAP2	Q96G30	MC2R	Homo sapiens	Q01718	Ub Reconstruction	28298427
Intra	MRAP2	Q96G30	MRAP2	Homo sapiens	Q96G30	BiFC	20371771
Intra	MRAP2	Q96G30	MRAP	Homo sapiens	Q8TCY5	BiFC	20371771
Intra	MRAP2	Q96G30	MRAP2	Homo sapiens	Q96G30	Anti Tag CoIP	19329486
Intra	MRAP2	Q96G30	MRAP	Homo sapiens	Q8TCY5	Anti Tag CoIP	19329486

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Body Mass Index Quantitative Trait Locus 18	Obesity BMIQ18 Obesity, Susceptibility To Obesity, Susceptibility To, Bmiq18 Obesity Bmiq18
Familial Glucocorticoid Deficiency	Glucocorticoid Deficiency Acth Resistance Adrenal Unresponsiveness To Acth Hereditary Unresponsiveness To Adrenocorticotropic Hormone Isolated Glucocorticoid Deficiency Glucocorticoid Deficiency, Familial Glucocorticoid Deficiency 1
Wilms Tumor, Aniridia, Genitourinary Anomalies, And Mental Retardation Syndrome	Wagr Syndrome 11p Partial Monosomy Syndrome Chromosome 11p13 Deletion Syndrome Wilms Tumor, Aniridia, Genitourinary Anomalies And Mental Retardation Syndrome 11p Deletion Syndrome Chromosome 11p Deletion Syndrome Wagr Complex Wilms Tumor-Aniridia-Genitourinary Anomalies-Intellectual Disability Syndrome Deletion 11p13 WAGR Wilms Tumor-Aniridia-Genitourinary Anomalies-Mental Retardation Syndrome Chromosome 11p Deletion 11p Deletion 11p Monosomy Deletion 11p Monosomy 11p Partial Monosomy 11p Agr Triad Wilms Tumor-Aniridia-Gonadoblastoma-Mental Retardation Syndrome Wilms Tumor, Aniridia, Genitourinary Anomalies, Mental Retardation Syndrome Wagr Contiguous Gene Syndrome Wilms Tumor-Aniridia-Genital Anomalies-Retardation Syndrome Wilms Tumor-Aniridia-Genitourinary Anomalies-Mr Syndrome Del(11)(P13) Monosomy 11p13 Chromosome 11, Deletion 11p

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08639	MRAP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22649	Mrap2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29163	Mrap2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MRAP2	RGD	RGD:1309873
Bos taurus	MRAP2	VGNC	VGNC:31596
Mus musculus	MRAP2	MGD	MGI:3609239
Canis familiaris	MRAP2	VGNC	VGNC:43357
Felis catus	MRAP2	VGNC	VGNC:63578
Others	MRAP2	NCBI