COX8A - cytochrome c oxidase subunit 8A Gene

Homo sapiens

Also known as COX; COX8; VIII; COX8L; COX8-2; VIII-L; MC4DN15

Gene ID: 1351 | Gene type: protein coding

About COX8A

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:63,974,620-63,976,543 (from NCBI)

This gene has 1 transcript (splice variant), 101 orthologues, 1 paralogue and is associated with 2 phenotypes. Ubiquitous expression in kidney (RPKM 159.8), colon (RPKM 143.7) and 25 other tissues.

Summary

The protein encoded by this gene is the terminal Enzyme of the respiratory chain, coupling the transfer of electrons from cytochrome c to molecular oxygen, with the concomitant production of a proton electrochemical gradient across the inner mitochondrial membrane. In addition to 3 mitochondrially encoded subunits, which perform the catalytic function, the eukaryotic Enzyme contains nuclear-encoded smaller subunits, ranging in number from 4 in some organisms to 10 in mammals. It has been proposed that nuclear-encoded subunits may be involved in the modulation of the catalytic function. This gene encodes one of the nuclear-encoded subunits. [provided by RefSeq, Jul 2008]

COX8A Products(1)

mRNA	Protein	Name
NM_004074.3	NP_004065.1	cytochrome c oxidase subunit 8A, mitochondrial

COX8A Protein Structure

COX8

0
69 a.a.

Protein Preferred Names

Protein Names

cytochrome c oxidase subunit 8A, mitochondrial

cytochrome c oxidase polypeptide VIII-liver/heart

Related Diseases

Diseases

Alias

Mitochondrial Complex Iv Deficiency, Nuclear Type 15

MC4DN15

Mitochondrial Complex 4 Deficiency, Nuclear Type 15

Isolated Cytochrome C Oxidase Deficiency

Isolated Cox Deficiency

Isolated Mitochondrial Respiratory Chain Complex Iv Deficiency

Mitochondrial Complex Iv Deficiency, Nuclear Type 1

Cytochrome C Oxidase Deficiency	Mitochondrial Complex Iv Deficiency
Cox Deficiency	Cytochrome-C Oxidase Deficiency Disease
MC1DN4	Cytochrome-C Oxidase Deficiency
MC4DN1	Mitochondrial Complex I Deficiency, Nuclear Type 4
Complex 4 Mitochondrial Respiratory Chain Deficiency	Complex Iv Deficiency
Mitochondrial Complex 1 Deficiency, Nuclear Type 4	Nuclear Type Mitochondrial Complex I Deficiency 4
Deficiency Of Mitochondrial Respiratory Chain Complex4	MT-C4D
Complex Iv Mitochondrial Respiratory Chain Deficiency	Lethal Neonatal Cardiomyopathy Hypertrophic Due To Cytochrome C Oxidase Deficiency
Mitochondrial Complex Iv Deficiency, Nuclear, Type 1

Cardiomyopathy, Familial Hypertrophic, 4

Hypertrophic Cardiomyopathy 4	CMH4
Cardiomyopathy, Hypertrophic, 4	Cardiomyopathy, Familial Hypertrophic 4
Cardiomyopathy, Familial Hypertrophic, 4, Susceptibility To	Cardiomyopathy, Hypertrophic, Familial, Type 4

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03078	COX8A Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	COX8A	VGNC	VGNC:107440
Mus musculus	COX8A	MGD	MGI:105959
Felis catus	COX8A	VGNC	VGNC:82003
Rattus norvegicus	COX8A	RGD	RGD:620638

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