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APOBEC3F - apolipoprotein B mRNA editing enzyme catalytic subunit 3F Gene

Also Known as A3F; KA6; ARP8; BK150C2.4.MRNA

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 200316

About APOBEC3F

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:39,040,864-39,055,972 (from NCBI)

This gene has 4 transcripts (splice variants), 52 orthologues and 9 paralogues. Broad expression in lymph node (RPKM 2.8), ovary (RPKM 2.8) and 24 other tissues.

Summary

This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing Enzymes and have roles in growth or cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

APOBEC3F Products (2)

mRNA	Protein	Name
NM_001006666.2	NP_001006667.1	DNA dC->dU-editing enzyme APOBEC-3F isoform b
NM_145298.6	NP_660341.2	DNA dC->dU-editing enzyme APOBEC-3F isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA binding	IDA IDA: Inferred from direct assay	11863358	GOA
enables cytidine deaminase activity	IDA IDA: Inferred from direct assay	17121840	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	23685212	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16699599	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	11863358	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA cytosine deamination	IDA IDA: Inferred from direct assay	21835787	GOA
involved in base conversion or substitution editing	IDA IDA: Inferred from direct assay	17121840	GOA
involved in clearance of foreign intracellular DNA	IDA IDA: Inferred from direct assay	20062055	GOA
involved in defense response to virus	IDA IDA: Inferred from direct assay	21835787	GOA
involved in innate immune response	IDA IDA: Inferred from direct assay	17121840	GOA
involved in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate	IDA IDA: Inferred from direct assay	17121840	GOA
involved in negative regulation of viral genome replication	IDA IDA: Inferred from direct assay	16378963	GOA
involved in negative regulation of viral process	IDA IDA: Inferred from direct assay	17121840	GOA
involved in positive regulation of defense response to virus by host	IDA IDA: Inferred from direct assay	17121840	GOA
involved in positive regulation of gene expression via chromosomal CpG island demethylation	IDA IDA: Inferred from direct assay	21496894	GOA
involved in retrotransposon silencing	IDA IDA: Inferred from direct assay	16527742	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in P-body	IDA IDA: Inferred from direct assay	16699599	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	16527742	GOA
part of ribonucleoprotein complex	IDA IDA: Inferred from direct assay	16699599	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

APOBEC3F Protein Structure

APOBEC_N

0
100
200
300
373 a.a.

Protein Preferred Names	Protein Names
DNA dC->dU-editing enzyme APOBEC-3F	apolipoprotein B editing enzyme catalytic polypeptide-like 3F

APOBEC3F Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	APOBEC3F	Q8IUX4	APOBEC3F	Homo sapiens	Q8IUX4	X-Ray Diffraction	23685212
Intra	APOBEC3F	Q8IUX4	APOBEC3F	Homo sapiens	Q8IUX4	DLS	23685212
Intra	APOBEC3F	Q8IUX4	TINF2	Homo sapiens	Q9BSI4	BiFC	21044950
Intra	APOBEC3F	Q8IUX4	APOBEC3G	Homo sapiens	Q9HC16	Anti Tag CoIP	15152192

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Primary Immunodeficiency Disease Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00839	APOBEC3F Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-120157	Vif-ElonginC interaction inhibitor 1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	APOBEC3F	MGD	MGI:1933111