APOBEC3G - apolipoprotein B mRNA editing enzyme catalytic subunit 3G Gene

Also Known as A3G; ARCD; ARP9; ARP-9; CEM15; CEM-15; MDS019; bK150C2.7; dJ494G10.1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 60489

About APOBEC3G

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:39,077,005-39,087,743 (from NCBI)

This gene has 7 transcripts (splice variants), 99 orthologues and 9 paralogues. Broad expression in lymph node (RPKM 19.7), spleen (RPKM 13.4) and 22 other tissues.

Summary

This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene catalyzes site-specific deamination of both RNA and single-stranded DNA. The encoded protein has been found to be a specific inhibitor of human immunodeficiency virus-1 (HIV-1) infectivity. [provided by RefSeq, Mar 2017]

APOBEC3G Products (4)

mRNA	Protein	Name
NM_001349436.1	NP_001336365.1	DNA dC->dU-editing enzyme APOBEC-3G isoform 2
NM_001349437.2	NP_001336366.1	DNA dC->dU-editing enzyme APOBEC-3G isoform 3
NM_001349438.3	NP_001336367.1	DNA dC->dU-editing enzyme APOBEC-3G isoform 4
NM_021822.4	NP_068594.1	DNA dC->dU-editing enzyme APOBEC-3G isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA binding	IDA IDA: Inferred from direct assay	11863358	GOA
enables cytidine deaminase activity	IDA IDA: Inferred from direct assay	12808465	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	11863358	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14528301	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	11863358	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA cytosine deamination	IDA IDA: Inferred from direct assay	16571802	GOA
involved in cytidine deamination	IDA IDA: Inferred from direct assay	16378963	GOA
involved in defense response to virus	IDA IDA: Inferred from direct assay	12808465	GOA
involved in innate immune response	IDA IDA: Inferred from direct assay	17121840	GOA
involved in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate	IDA IDA: Inferred from direct assay	16571802	GOA
involved in negative regulation of viral genome replication	IDA IDA: Inferred from direct assay	16378963	GOA
involved in negative regulation of viral process	IDA IDA: Inferred from direct assay	17121840	GOA
involved in positive regulation of defense response to virus by host	IDA IDA: Inferred from direct assay	17121840	GOA
involved in retrotransposon silencing	IDA IDA: Inferred from direct assay	16527742	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in P-body	IDA IDA: Inferred from direct assay	16699599	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	16527742	GOA
part of ribonucleoprotein complex	IDA IDA: Inferred from direct assay	16699599	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

APOBEC3G Protein Structure

APOBEC_N

0
100
200
300
384 a.a.

Protein Preferred Names	Protein Names
DNA dC->dU-editing enzyme APOBEC-3G	APOBEC-related cytidine deaminase

APOBEC3G Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	APOBEC3G	Q9HC16	vif	Human immunodeficiency virus	Q77YG0	Pull Down	19887642
Intra	APOBEC3G	Q9HC16	vif	Human immunodeficiency virus	Q77YG0	Anti Tag CoIP	18836454
Intra	APOBEC3G	Q9HC16	PRKACA	Homo sapiens	P17612	Anti Tag CoIP	18836454
Intra	APOBEC3G	Q9HC16	PRKACA	Homo sapiens	P17612	Protein Kinase Assay	18836454
Intra	APOBEC3G	Q9HC16	APOBEC3G	Homo sapiens	Q9HC16	X-Ray Diffraction	20152150
Intra	APOBEC3G	Q9HC16	APOBEC3G	Homo sapiens	Q9HC16	Anti Tag CoIP	15152192
Intra	APOBEC3G	Q9HC16	N	Human SARS coronavirus	P59595	Pull Down	19345973
Intra	APOBEC3G	Q9HC16	CEBPB	Homo sapiens	P17676	Anti Tag CoIP	18809921
Intra	APOBEC3G	Q9HC16	N	Human coronavirus 229E	P15130	Pull Down	19345973
Intra	APOBEC3G	Q9HC16	ubiq_human	Homo sapiens	DIP-24261N	Anti Tag CoIP	18836454
Intra	APOBEC3G	Q9HC16	vif	Human immunodeficiency virus	P69723	Anti Tag CoIP	14528301
Intra	APOBEC3G	Q9HC16	vif	Human immunodeficiency virus	P69723	Anti Tag CoIP	15152192
Intra	APOBEC3G	Q9HC16	vif	Human immunodeficiency virus	P12504	Anti Tag CoIP	12859895
Intra	APOBEC3G	Q9HC16	C	Hepatitis B virus	Q784Z8	FRET	24557838

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Hepatitis B	Chronic Hepatitis B Hepatitis B Infection Serum Hepatitis HBV Hepatitis B Chronic Hbv, Susceptibility To Hepatitis B, Chronic Chronic Hepatitis B Without Delta Agent Chronic Hbv - [Hepatitis B Virus] Infection Hepatitis B Nos Chronic Type B Viral Hepatitis Hep B Nos
Hepatitis	Chronic Hepatitis Chronic Persistent Hepatitis Acute Hepatitis Hepatitis, Chronic Acute And Subacute Liver Necrosis Acute/Subac. Necrosis Of Liver Animal Hepatitis Hepatitis Chronic Hepatitis A Hepatitis, Animal Hepatitis Due To Toxoplasmosis Hepatitis In Toxoplasmosis Toxoplasmal Hepatitis Chronic Hepatitis, Unspecified Chronic Active Hepatitis Nec Other Specified Chronic Hepatitis Chronic Persistent Hepatitis Nec Chronic Lobular Hepatitis Nec
Human Immunodeficiency Virus Infectious Disease	Hiv Infections
Human Immunodeficiency Virus Type 1	Aids Hiv/Aids Aids, Delayed/Rapid Progression To Hiv-1, Susceptibility To Hiv-1 Viremia, Susceptibility To Human Immunodeficiency Virus Type 1, Susceptibility To Hiv-1 Aids, Slow Progression To Rapid Progression To Aids From Hiv1 Infection Hiv1 Infection, Resistance To Hiv1 Infection Hiv-1 Viremia Aids, Resistance To Aids, Rapid Progression To Hiv/Aids, Susceptibility To Hiv-1, Resistance To Hiv1, Resistance To Hiv1 Hiv-1 Disease, Delayed Progression Of Hiv-1 Disease, Rapid Progression Of Hiv Infection, Resistance To Hiv Type 1, Susceptibility To Hiv Type 1 Hiv-1 Infection Human Immunodeficiency Virus I Infection Acquired Immunodeficiency Syndrome Hiv-Infection/Aids
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Primary Immunodeficiency Disease Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Aicardi-Goutieres Syndrome	Aicardi Goutieres Syndrome Cree Encephalitis Aicardi-Goutières Syndrome Encephalopathy With Basal Ganglia Calcification Ags Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid Pseudotoxoplasmosis Syndrome Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis Aicardi-Goutieres Syndrome 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W279260	APOBEC3G-IN-1	Inhibitor	96.88%	Unkown
HY-148138	Deaminase inhibitor-1	Inhibitor	99.62%	Unkown
HY-122156	IMB-301	Inhibitor	99.08%	Unkown
HY-148042	HIV-1 inhibitor-47	Inhibitor	98.0%	Unkown
HY-RS00840	APOBEC3G Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-124870	N.41	Inhibitor	/	Unkown
HY-183925	Redoxal	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	APOBEC3G	MGD	MGI:1933111
Others	APOBEC3G	NCBI