SALL3 - spalt like transcription factor 3 Gene

Homo sapiens

Also known as ZNF796

Gene ID: 27164 | Gene type: protein coding

About SALL3

Cytogenetic location: 18q23 Genomic coordinates (GRCh38): 18:78,979,818-78,998,969 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele, 196 orthologues and 14 paralogues. Biased expression in brain (RPKM 1.5), prostate (RPKM 0.7) and 2 other tissues.

Summary

This gene encodes a sal-like C2H2-type zinc-finger protein, and belongs to a family of evolutionarily conserved genes found in species as diverse as Drosophila, C. elegans, and vertebrates. Mutations in some of these genes are associated with congenital disorders in human, suggesting their importance in embryonic development. This protein binds to DNA Methyltransferase 3 alpha (DNMT3A), and reduces DNMT3A-mediated CpG island methylation. It is suggested that silencing of this gene, resulting in acceleration of DNA methylation, may have a role in oncogenesis. [provided by RefSeq, Oct 2011]

SALL3 Products(1)

mRNA	Protein	Name
NM_171999.4	NP_741996.2	sal-like protein 3

SALL3 Protein Structure

zf-H2C2_2

zf-C2H2_4

zf-H2C2_2

0
200
400
600
800
1000
1200
1300 a.a.

Protein Preferred Names

Protein Names

sal-like protein 3

C2H2 zinc finger protein SALL3

Related Diseases

Diseases

Alias

Ivic Syndrome

Oculootoradial Syndrome	Radial Ray Defects, Hearing Impairment, External Ophthalmoplegia, And Thrombocytopenia
IVIC	Instituto Venezolano De Investigaciones Cientificas Syndrome
Oculo-Oto-Radial Syndrome	Oors

Duane-Radial Ray Syndrome

Okihiro Syndrome	DRRS
Dr Syndrome	Duane Anomaly With Radial Ray Abnormalities And Deafness
Acrorenoocular Syndrome	Acrorenocular Syndrome
Duane Anomaly With Radial Abnormalities And Deafness	Acro-Renal-Ocular Syndrome

Ureteral Benign Neoplasm

Neoplasm Of Ureter	Ureteral Tumor
Cancer Of The Ureter	Malignant Tumour Of Ureter
Ureteric Cancer	Primary Malignant Neoplasm Of Ureter

Townes-Brocks Syndrome

Townes Syndrome	Renal-Ear-Anal-Radial Syndrome
Anus, Imperforate, With Hand, Foot And Ear Anomalies	Imperforate Anus-Hand, Foot And Ear Anomalies Syndrome
Rear Syndrome	Sensorineural Deafness With Imperforate Anus And Hypoplastic Thumbs
Tbs	Deafness, Sensorineural, With Imperforate Anus And Hypoplastic Thumbs
Imperforate Anus With Hand, Foot And Ear Anomalies	Anal-Ear-Renal-Radial Malformation Syndrome
Deafness-Imperforate Anus-Hypoplastic Thumbs Syndrome	Imperforate Anus-Hand And Foot Anomalies Syndrome
Sensorineural Deafness-Imperforate Anus-Hypoplastic Thumbs Syndrome	Sensorineural Hearing Loss With Imperforate Anus And Hypoplastic Thumbs

Chromosome 18q Deletion Syndrome

18q- Syndrome	Monosomy 18q
Deletion Of Long Arm Of Chromosome 18	Chromosome 18q- Syndrome
Deletion 18q	18q Deletion Syndrome
Distal 18q Deletion Syndrome	Chromosome 18 Long Arm Deletion Syndrome
Chromosome 18q Monosomy	Del Syndrome
Chromosome 18 Deletion Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12419	SALL3 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SALL3	RGD	RGD:1310232
Macaca mulatta	SALL3	VGNC	VGNC:76967
Mus musculus	SALL3	MGD	MGI:109295
Felis catus	SALL3	VGNC	VGNC:64858
Bos taurus	SALL3	VGNC	VGNC:106912
Canis familiaris	SALL3	VGNC	VGNC:49643

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