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FAM135B - family with sequence similarity 135 member B Gene

Also Known as C8ORFK32

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51059

About FAM135B

This gene has 11 transcripts (splice variants), 238 orthologues, 1 paralogue and is associated with 93 phenotypes. Biased expression in testis (RPKM 3.0), brain (RPKM 2.6) and 4 other tissues.

Summary

Predicted to be involved in cellular lipid metabolic process. [provided by Alliance of Genome Resources, Apr 2022]

FAM135B Products (2)

mRNA	Protein	Name
NM_001362965.2	NP_001349894.1	protein FAM135B
NM_015912.4	NP_056996.2	protein FAM135B

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	24705354	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FAM135B Protein Structure

DUF3657

DUF676

0
300
600
900
1200
1406 a.a.

Protein Preferred Names	Protein Names
protein FAM135B

FAM135B Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FAM135B	Q49AJ0	ZDHHC17	Homo sapiens	Q8IUH5	Anti Tag CoIP	33961781
Intra	FAM135B	Q49AJ0	ZDHHC17	Homo sapiens	Q8IUH5	Y2H Array	24705354

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Amelogenesis Imperfecta, Type Iiia	Ai3 Adhcai Amelogenesis Imperfecta Type 3 AI3A Amelogenesis Imperfecta, Type Iii Amelogenesis Imperfecta, Hypocalcification Type, Autosomal Dominant Amelogenesis Imperfecta Type 3a Amelogenesis Imperfecta Hypomineralization Type Amelogenesis Imperfecta Type Iii Hypocalcified Amelogenesis Imperfecta Amelogenesis Imperfecta, Type 3 Amelogenesis Imperfecta, Hypomineralization Type Autosomal Dominant Amelogenesis Imperfecta Hypocalcification Type Amelogenesis Imperfecta 3a Amelogenesis Imperfecta Hypocalcification Type Autosomal Dominant

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04684	FAM135B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	FAM135B	VGNC	VGNC:81656
Mus musculus	FAM135B	MGD	MGI:1917613
Bos taurus	FAM135B	VGNC	VGNC:106730
Canis familiaris	FAM135B	VGNC	VGNC:40595
Macaca mulatta	FAM135B	VGNC	VGNC:72382
Rattus norvegicus	FAM135B	RGD	RGD:1308133
Others	FAM135B	NCBI