LRRC7 - leucine rich repeat containing 7 Gene

Also Known as DENSIN

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57554

About LRRC7

Cytogenetic location: 1p31.1 Genomic coordinates (GRCh38): 1:69,567,922-70,144,364 (from NCBI)

This gene has 14 transcripts (splice variants), 208 orthologues and 31 paralogues. Biased expression in brain (RPKM 2.3), testis (RPKM 0.6) and 2 other tissues.

Summary

Predicted to be involved in several processes, including establishment or maintenance of epithelial cell apical/basal polarity; positive regulation of neuron projection development; and receptor clustering. Located in several cellular components, including centrosome; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

LRRC7 Products (10)

mRNA Protein Name
NM_001330635.3 NP_001317564.1 leucine-rich repeat-containing protein 7 isoform 2
NM_001350216.3 NP_001337145.1 leucine-rich repeat-containing protein 7 isoform 3
NM_001366836.3 NP_001353765.1 leucine-rich repeat-containing protein 7 isoform 4
NM_001366837.3 NP_001353766.1 leucine-rich repeat-containing protein 7 isoform 5
NM_001366838.3 NP_001353767.1 leucine-rich repeat-containing protein 7 isoform 6
NM_001366839.3 NP_001353768.1 leucine-rich repeat-containing protein 7 isoform 7
NM_001366840.1 NP_001353769.1 leucine-rich repeat-containing protein 7 isoform 8
NM_001366841.1 NP_001353770.1 leucine-rich repeat-containing protein 7 isoform 9
NM_001366842.1 NP_001353771.1 leucine-rich repeat-containing protein 7 isoform 10
NM_001370785.2 NP_001357714.1 leucine-rich repeat-containing protein 7 isoform 11

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12390249 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LRRC7 Protein Structure

LRR_1

LRR_1: Leucine Rich Repeat (93 - 114)

LRR_4

LRR_4: Leucine Rich repeats (2 copies) (162 - 200)

LRR_8

LRR_8: Leucine rich repeat (208 - 265)

LRR_4

LRR_4: Leucine Rich repeats (2 copies) (345 - 383)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (1453 - 1532)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1537 a.a.
Protein Preferred Names Protein Names

leucine-rich repeat-containing protein 7

  • densin-180

LRRC7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
LRRC7 Q96NW7 Cnksr2 Rattus norvegicus Q9Z1T4
Y2H Array
12390249
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Psoriasis 9

  • PSORS9

  • Psoriasis 9, Susceptibility To

  • Psoriasis Susceptibility 9
Cri-Du-Chat Syndrome

  • 5p Deletion Syndrome

  • 5p Partial Monosomy Syndrome

  • Monosomy 5p

  • Cat Cry Syndrome

  • Chromosome 5p Deletion Syndrome

  • Cri Du Chat Syndrome

  • 5p- Syndrome

  • 5p Minus Syndrome

  • Chromosome 5p- Syndrome

  • Chromosome 5 Short Arm Deletion Syndrome

  • Chromosome 5p Deletion

  • Deletion 5p

  • Cri Du Chat

  • 5p Partial Deletion Syndrome

  • Partial Deletion Of Short Arm Of Chromosome 5 Syndrome
Hypomelanosis Of Ito

  • Incontinentia Pigmenti Achromians

  • Nevus Of Ito

  • Ipa

  • Ito Hypomelanosis

  • Ito

  • Pigmentation Disorders

  • HMI

  • Incontinentia Pigmenti, Type I, Formerly

  • Ip1, Formerly

  • Bloch-Siemans Syndrome

  • Incontinentia Pigmenti Achromians Syndrome

  • Ito'S Nevus

  • Incontinentia Pigmenti Type 1

  • Nevi Of Ito

  • Nevus Fuscocaeruleus Acromiodeltoideus

  • Bloch Sulzberger Syndrome

  • Skin Pigmentation Disorder
Trichorhinophalangeal Syndrome, Type Ii

  • Langer-Giedion Syndrome

  • Lgs

  • Trichorhinophalangeal Syndrome Type Ii

  • Trichorhinophalangeal Syndrome Type 2

  • TRPS2

  • Monosomy 8q24.1

  • Chromosome 8q24.1 Deletion Syndrome

  • Deletion 8q24.1

  • Giedion-Langer Syndrome

  • Trichorhinophalangeal Dysplasia Type Ii

  • Langer Giedion Syndrome

  • Trps 2

  • Tricho-Rhino-Phalangeal Syndrome Type Ii

  • Trichorhinophalangeal Syndrome With Exostosis

  • Trps Ii

  • Tricho-Rhino-Phalangeal Syndrome 2

  • 8q24.1 Microdeletion Syndrome

  • 8q24.1 Deletion Syndrome
Galloway-Mowat Syndrome

  • Galloway Mowat Syndrome

  • Galloway Syndrome

  • Hiatal Hernia-Microcephaly-Nephrosis, Galloway Type

  • Microcephaly Nephrosis Syndrome

  • Microcephaly, Hiatal Hernia, And Nephrotic Syndrome

  • Nephrosis Neuronal Dysmigration Syndrome

  • Microcephaly-Hiatus Hernia-Nephrotic Syndrome

  • Nephrosis-Neuronal Dysmigration Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07826 LRRC7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus LRRC7 RGD RGD:708527
Canis familiaris LRRC7 VGNC VGNC:54044
Mus musculus LRRC7 MGD MGI:2676665
Felis catus LRRC7 VGNC VGNC:107575
Macaca mulatta LRRC7 VGNC VGNC:100002
Bos taurus LRRC7 VGNC VGNC:55251
Others LRRC7 NCBI