Cnksr2 - connector enhancer of kinase suppressor of Ras 2 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 59322

Summary

Enables identical protein binding activity. Involved in postsynapse organization. Located in several cellular components, including neuronal cell body; postsynaptic density; and postsynaptic membrane. Is active in glutamatergic synapse. Is extrinsic component of postsynaptic density membrane. Human ortholog(s) of this gene implicated in syndromic X-linked mental retardation Hough type. Orthologous to human CNKSR2 (connector enhancer of kinase suppressor of Ras 2). [provided by Alliance of Genome Resources, Apr 2022]

Cnksr2 Products (2)

mRNA Protein Name
NM_001113366.1 NP_001106837.1 connector enhancer of kinase suppressor of ras 2 isoform 1
NM_021686.3 NP_067718.1 connector enhancer of kinase suppressor of ras 2 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
12390249 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
12390249 RGD
Biological Process GO Annotation Evidence References Source
involved in postsynapse organization IDA
IDA: Inferred from direct assay
24656827 RGD
involved in postsynapse organization IMP
IMP: Inferred from mutant phenotype
24656827 RGD
involved in postsynaptic specialization organization IDA
IDA: Inferred from direct assay
32235845 RGD
involved in postsynaptic specialization organization IMP
IMP: Inferred from mutant phenotype
32235845 RGD
Cellular Component GO Annotation Evidence References Source
is active in extrinsic component of postsynaptic density membrane IDA
IDA: Inferred from direct assay
10207009 RGD
is active in extrinsic component of postsynaptic density membrane IMP
IMP: Inferred from mutant phenotype
10207009 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
10207009 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
10207009 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
10207009 RGD
located in postsynaptic membrane IDA
IDA: Inferred from direct assay
10207009 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

connector enhancer of kinase suppressor of ras 2

  • CNK homolog protein 2

  • CNK2

  • connector enhancer of KSR 2

  • maguin

  • maguin-1

  • maguin-2

  • membrane-associated guanylate kinase-interacting protein

Cnksr2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Cnksr2 Q9Z1T4 Dlg4 Rattus norvegicus P31016
Anti Bait CoIP
12390249
Intra
Cnksr2 Q9Z1T4 LRRC7 Homo sapiens Q96NW7
Pull Down
12390249
Intra
Cnksr2 Q9Z1T4 Lrrc7 Rattus norvegicus P70587
Anti Bait CoIP
12390249
Intra
Cnksr2 Q9Z1T4 Cnksr2 Rattus norvegicus Q9Z1T4
Y2H
12390249
Intra
Cnksr2 Q9Z1T4 Cnksr2 Rattus norvegicus Q9Z1T4
Anti Tag CoIP
12390249
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02889 CNKSR2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cnksr2 NCBI NCBI:22866