Lrrc7 - leucine rich repeat containing 7 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 117284

Summary

Enables protein C-terminus binding activity. Involved in positive regulation of neuron projection development and response to organic cyclic compound. Located in several cellular components, including axon initial segment; dendritic spine; and postsynaptic density. Is active in glutamatergic synapse. Is integral component of postsynaptic density membrane. Colocalizes with actin Cytoskeleton. Orthologous to human LRRC7 (leucine rich repeat containing 7). [provided by Alliance of Genome Resources, Apr 2022]

Lrrc7 Products (2)

mRNA Protein Name
NM_001393674.1 NP_001380603.1 leucine-rich repeat-containing protein 7 isoform 1
NM_057142.2 NP_476483.1 leucine-rich repeat-containing protein 7 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
12390249 RGD
enables protein kinase binding IPI
IPI: Inferred from physical interaction
16120608 RGD
Biological Process GO Annotation Evidence Verweise Source
involved in positive regulation of neuron projection development IDA
IDA: Inferred from direct assay
15647492 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
19038319 RGD
Cellular Component GO Annotation Evidence Verweise Source
located in actin cytoskeleton IDA
IDA: Inferred from direct assay
18248607 RGD
located in axon initial segment IDA
IDA: Inferred from direct assay
8824323 RGD
located in dendritic spine IDA
IDA: Inferred from direct assay
8824323 RGD
located in filopodium IDA
IDA: Inferred from direct assay
18248607 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
8824323 RGD
is active in postsynaptic density membrane IDA
IDA: Inferred from direct assay
8824323 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

leucine-rich repeat-containing protein 7

  • densin 13T-16

  • densin 13T-17

  • densin 13T-23

  • densin 13T-29

  • densin 13T-41

  • densin 13T-43

  • densin 13T-57

  • densin 13T-57C

  • densin 13T-72

  • densin 13T-89

  • densin-180

Lrrc7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
Lrrc7 P70587 Camk2a Rattus norvegicus P11275
Anti Bait CoIP
16120608
Intra
Lrrc7 P70587 Dlg4 Rattus norvegicus P31016
Anti Tag CoIP
12390249
Intra
Lrrc7 P70587 Dlg4 Rattus norvegicus P31016
IF
12390249
Intra
Lrrc7 P70587 Dlg4 Rattus norvegicus P31016
Anti Bait CoIP
12390249
Cross
Lrrc7 P70587 Camk2a Mus musculus P11798
Filter Binding
16120608
Cross
Lrrc7 P70587 Camk2a Mus musculus P11798
Pull Down
16120608
Intra
Lrrc7 P70587 Cnksr2 Rattus norvegicus Q9Z1T4
Anti Bait CoIP
12390249
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS07826 LRRC7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lrrc7 NCBI NCBI:57554