Dlg4 - discs large MAGUK scaffold protein 4 Gene

Also Known as Dlgh4; PSD95; Sap90

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29495

Summary

Enables several functions, including PDZ domain binding activity; enzyme binding activity; and signaling receptor binding activity. A structural constituent of postsynaptic density. Involved in several processes, including modulation of chemical synaptic transmission; positive regulation of cellular component organization; and postsynapse organization. Located in several cellular components, including dendrite; juxtaparanode region of axon; and postsynaptic density. Is active in glutamatergic synapse. Is anchored component of postsynaptic density membrane. Colocalizes with postsynaptic membrane. Biomarker of Parkinson's disease and temporal lobe epilepsy. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability. Orthologous to human DLG4 (discs large MAGUK scaffold protein 4). [provided by Alliance of Genome Resources, Apr 2022]

Dlg4 Products (1)

mRNA Protein Name
NM_019621.2 NP_062567.1 disks large homolog 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables D1 dopamine receptor binding IPI
IPI: Inferred from physical interaction
23041629 RGD
enables P2Y1 nucleotide receptor binding IPI
IPI: Inferred from physical interaction
20847060 RGD
enables PDZ domain binding IMP
IMP: Inferred from mutant phenotype
25424568 RGD
enables PDZ domain binding IPI
IPI: Inferred from physical interaction
10644767 RGD
enables acetylcholine receptor binding IDA
IDA: Inferred from direct assay
22593058 RGD
enables beta-1 adrenergic receptor binding IPI
IPI: Inferred from physical interaction
11526121 RGD
enables beta-2 adrenergic receptor binding IPI
IPI: Inferred from physical interaction
20395454 RGD
enables frizzled binding IPI
IPI: Inferred from physical interaction
25424568 RGD
enables glutamate receptor binding IPI
IPI: Inferred from physical interaction
20847060 RGD
enables ionotropic glutamate receptor binding IPI
IPI: Inferred from physical interaction
10414981 RGD
enables kinesin binding IPI
IPI: Inferred from physical interaction
12097473 RGD
enables neuroligin family protein binding IPI
IPI: Inferred from physical interaction
11368788 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
1127911 RGD
enables protein kinase binding IPI
IPI: Inferred from physical interaction
20220006 RGD
enables protein phosphatase binding IPI
IPI: Inferred from physical interaction
20410104 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
11178875 RGD
enables scaffold protein binding IPI
IPI: Inferred from physical interaction
10939335 RGD
enables signaling receptor binding IPI
IPI: Inferred from physical interaction
9808460 RGD
enables structural constituent of postsynaptic density IDA
IDA: Inferred from direct assay
21525273 RGD
enables structural constituent of postsynaptic density IMP
IMP: Inferred from mutant phenotype
21525273 RGD
Biological Process GO Annotation Evidence References Source
involved in AMPA glutamate receptor clustering IMP
IMP: Inferred from mutant phenotype
21525273 RGD
involved in NMDA selective glutamate receptor signaling pathway IDA
IDA: Inferred from direct assay
12930820 RGD
involved in cerebral cortex development IEP
IEP: Inferred from expression pattern
14597197 RGD
involved in dendritic spine morphogenesis IMP
IMP: Inferred from mutant phenotype
21525273 RGD
involved in dendritic spine organization IMP
IMP: Inferred from mutant phenotype
26679993 RGD
involved in negative regulation of receptor internalization IDA
IDA: Inferred from direct assay
11526121 RGD
involved in positive regulation of AMPA glutamate receptor clustering IMP
IMP: Inferred from mutant phenotype
19596852 RGD
involved in positive regulation of cytosolic calcium ion concentration IMP
IMP: Inferred from mutant phenotype
20531396 RGD
involved in positive regulation of dendrite morphogenesis IMP
IMP: Inferred from mutant phenotype
25424568 RGD
involved in positive regulation of excitatory postsynaptic potential IDA
IDA: Inferred from direct assay
12930820 RGD
involved in positive regulation of excitatory postsynaptic potential IMP
IMP: Inferred from mutant phenotype
12930820 RGD
involved in positive regulation of neuron projection arborization IGI
IGI: Inferred from genetic interaction
25424568 RGD
involved in positive regulation of synapse assembly IMP
IMP: Inferred from mutant phenotype
26738857 RGD
involved in positive regulation of synaptic transmission IDA
IDA: Inferred from direct assay
12930820 RGD
involved in protein localization to synapse IMP
IMP: Inferred from mutant phenotype
12097487 RGD
involved in receptor localization to synapse IMP
IMP: Inferred from mutant phenotype
21525273 RGD
involved in regulation of NMDA receptor activity IMP
IMP: Inferred from mutant phenotype
12930820 RGD
involved in regulation of neuronal synaptic plasticity IMP
IMP: Inferred from mutant phenotype
19596852 RGD
Cellular Component GO Annotation Evidence References Source
located in cell-cell junction IDA
IDA: Inferred from direct assay
26595655 RGD
located in dendrite IDA
IDA: Inferred from direct assay
11931740 RGD
located in dendrite cytoplasm IDA
IDA: Inferred from direct assay
1419001 RGD
located in dendritic branch IDA
IDA: Inferred from direct assay
20802490 RGD
located in dendritic spine IDA
IDA: Inferred from direct assay
26679993 RGD
located in excitatory synapse IDA
IDA: Inferred from direct assay
19730411 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
20357126 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
21525273 RGD
located in juxtaparanode region of axon IDA
IDA: Inferred from direct assay
19109503 RGD
located in membrane IDA
IDA: Inferred from direct assay
20089912 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
20847060 RGD
located in postsynaptic density IDA
IDA: Inferred from direct assay
1419001 RGD
is active in postsynaptic density membrane IDA
IDA: Inferred from direct assay
20357126 RGD
located in postsynaptic membrane IDA
IDA: Inferred from direct assay
11483650 RGD
located in proximal dendrite IDA
IDA: Inferred from direct assay
20802490 RGD
located in synapse IDA
IDA: Inferred from direct assay
11483650 RGD
located in synapse IMP
IMP: Inferred from mutant phenotype
27307232 RGD
located in synaptic membrane IDA
IDA: Inferred from direct assay
10414981 RGD
part of voltage-gated potassium channel complex IDA
IDA: Inferred from direct assay
20089912 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

disks large homolog 4

  • PSD-95

  • SAP-90

  • discs, large homolog 4

  • postsynaptic density protein 95

  • synapse-associated protein 90

  • synapse-associated protein SAP90

Dlg4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Dlg4 P31016 Vangl1 Mus musculus Q80Z96
Anti Tag CoIP
23567299
Cross
Dlg4 P31016 Vangl1 Mus musculus Q80Z96
Pull Down
23567299
Cross
Dlg4 P31016 Vangl2 Mus musculus Q91ZD4
Pull Down
23567299
Cross
Dlg4 P31016 Vangl2 Mus musculus Q91ZD4
Anti Tag CoIP
23567299
Cross
Dlg4 P31016 GRIN2B Homo sapiens Q13224
FPS
11937501
Cross
Dlg4 P31016 Src Mus musculus P05480
Pull Down
16990796
Cross
Dlg4 P31016 Src Mus musculus P05480
Anti Bait CoIP
16990796
Cross
Dlg4 P31016 DLG1 Homo sapiens Q12959-2
Anti Tag CoIP
16332687
Cross
Dlg4 P31016 DLG1 Homo sapiens Q12959-2
Pull Down
16332687
Cross
Dlg4 P31016 DLG1 Homo sapiens Q12959-2
Anti Bait CoIP
16332687
Intra
Dlg4 P31016 Gria1 Rattus norvegicus P19490
Anti Bait CoIP
29222408
Intra
Dlg4 P31016 Gria1 Rattus norvegicus P19490
IF
29222408
Intra
Dlg4 P31016 Dlg1 Rattus norvegicus Q62696
Anti Bait CoIP
16332687
Intra
Dlg4 P31016 Grin2b Rattus norvegicus Q00960
Anti Bait CoIP
7569905
Intra
Dlg4 P31016 Grin2b Rattus norvegicus Q00960
Anti Bait CoIP
10341223
Intra
Dlg4 P31016 Grin2b Rattus norvegicus Q00960
Filter Binding
8601796
Intra
Dlg4 P31016 Grin2b Rattus norvegicus Q00960
Anti Bait CoIP
16990796
Intra
Dlg4 P31016 Grin2b Rattus norvegicus Q00960
Y2H
7569905
Intra
Dlg4 P31016 Grin2b Rattus norvegicus Q00960
Y2H
8601796
Intra
Dlg4 P31016 Grin2b Rattus norvegicus Q00960
Competition Binding
9786987
Intra
Dlg4 P31016 Grin2b Rattus norvegicus Q00960
Anti Bait CoIP
23567299
Intra
Dlg4 P31016 Grin2b Rattus norvegicus Q00960
Pull Down
7569905
Intra
Dlg4 P31016 Grin2a Rattus norvegicus Q00959
Pull Down
11222640
Intra
Dlg4 P31016 Grin2a Rattus norvegicus Q00959
Y2H
7569905
Intra
Dlg4 P31016 Grin2a Rattus norvegicus Q00959
Y2H Array
10336672
Cross
Dlg4 P31016 KCNA4 Homo sapiens P22459
ELISA
11937501
Cross
Dlg4 P31016 KCNA4 Homo sapiens P22459
Pull Down
9786987
Cross
Dlg4 P31016 KCNA4 Homo sapiens P22459
FPS
11937501
Intra
Dlg4 P31016 Map1a Rattus norvegicus P34926
Filter Binding
9786987
Intra
Dlg4 P31016 Map1a Rattus norvegicus P34926
Peptide Array
17220895
Intra
Dlg4 P31016 Map1a Rattus norvegicus P34926
Pull Down
17220895
Intra
Dlg4 P31016 Map1a Rattus norvegicus P34926
NMR
17220895
Intra
Dlg4 P31016 Map1a Rattus norvegicus P34926
Far-WB
9786987
Intra
Dlg4 P31016 Apc Rattus norvegicus P70478
Competition Binding
9786987
Intra
Dlg4 P31016 Wipf1 Rattus norvegicus Q6IN36
Pull Down
16990791
Cross
Dlg4 P31016 GRIN2A Homo sapiens Q12879
FPS
11937501
Intra
Dlg4 P31016 Tamalin Rattus norvegicus Q8R4T5
Anti Bait CoIP
12586822
Intra
Dlg4 P31016 Tamalin Rattus norvegicus Q8R4T5
Pull Down
12586822
Intra
Dlg4 P31016 Gucy1a2 Rattus norvegicus Q9WVI4
Pull Down
11572861
Intra
Dlg4 P31016 Sstr4 Rattus norvegicus P30937
Anti Tag CoIP
17950729
Intra
Dlg4 P31016 Sstr4 Rattus norvegicus P30937
Anti Bait CoIP
17950729
Intra
Dlg4 P31016 Sstr4 Rattus norvegicus P30937
IF
17950729
Intra
Dlg4 P31016 Lrrc7 Rattus norvegicus P70587
Anti Bait CoIP
12390249
Intra
Dlg4 P31016 Pten Rattus norvegicus O54857
Anti Bait CoIP
20628354
Intra
Dlg4 P31016 Pten Rattus norvegicus O54857
Density Sedimentation
20628354
Intra
Dlg4 P31016 Dlgap1 Rattus norvegicus P97836
Protein Array
9115257
Intra
Dlg4 P31016 Dlgap1 Rattus norvegicus P97836
Imaging
9115257
Intra
Dlg4 P31016 Dlgap1 Rattus norvegicus P97836
Anti Bait CoIP
11178875
Intra
Dlg4 P31016 Shank1 Rattus norvegicus Q9WV48
Anti Bait CoIP
11178875
Intra
Dlg4 P31016 Slc6a9 Rattus norvegicus P28572
Anti Bait CoIP
16271045
Intra
Dlg4 P31016 Slc6a9 Rattus norvegicus P28572-2
Anti Bait CoIP
16271045
Intra
Dlg4 P31016 Slc6a9 Rattus norvegicus P28572-2
Pull Down
16271045
Intra
Dlg4 P31016 Slc6a9 Rattus norvegicus P28572-2
Y2H
16271045
Intra
Dlg4 P31016 Cacng2 Rattus norvegicus Q71RJ2
Pull Down
12359873
Intra
Dlg4 P31016 Cnksr2 Rattus norvegicus Q9Z1T4
Anti Bait CoIP
12390249
Intra
Dlg4 P31016 Cnksr2 Rattus norvegicus Q9Z1T4
Anti Tag CoIP
12390249
Intra
Dlg4 P31016 Cnksr2 Rattus norvegicus Q9Z1T4
IF
12390249
Intra
Dlg4 P31016 Dgkz Rattus norvegicus O08560
Anti Bait CoIP
19229292
Intra
Dlg4 P31016 Dgkz Rattus norvegicus O08560
Y2H
19229292
Intra
Dlg4 P31016 Dgkz Rattus norvegicus O08560
IF
19229292
Intra
Dlg4 P31016 Lrfn2 Rattus norvegicus Q460M5
IF
16495444
Intra
Dlg4 P31016 Grin1 Rattus norvegicus P35439
Anti Bait CoIP
23567299
Intra
Dlg4 P31016 Grin1 Rattus norvegicus P35439
Anti Bait CoIP
20628354
Intra
Dlg4 P31016 Grin1 Rattus norvegicus P35439
Density Sedimentation
20628354
Cross
Dlg4 P31016 CRIPT Homo sapiens Q9P021
ELISA
11937501
Cross
Dlg4 P31016 ADRB1 Homo sapiens P08588
Peptide Array
16316992
Cross
Dlg4 P31016 ADRB1 Homo sapiens P08588
Far-WB
16533813
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Dlg4 Proteins

Cat. No. Product Name Accession Purity
HY-P71010 PSD95 Protein, Rat (His) NP_062567 (M1-L724) ≥ 80%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS28659 Dlg4 Rat Pre-designed siRNA Set A / Unkown
HY-RS03799 DLG4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07700 LLGL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22138 Dlg4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dlg4 NCBI NCBI:1742