PSD95 Protein, Rat (His)
PSD95 protein plays a crucial role in PDZ domain binding, enzyme binding and signaling receptor binding. It is a structural component of the postsynaptic density and is involved in the regulation of synaptic transmission and cellular organization. PSD95 Protein, Rat (His) is the recombinant rat-derived PSD95 protein, expressed by E. coli , with N-6*His labeled tag.
- Species: Rat
- Source: E. coli
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Biological Activity
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Product Properties
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Biological Activity
PSD95 protein plays a crucial role in PDZ domain binding, enzyme binding and signaling receptor binding. It is a structural component of the postsynaptic density and is involved in the regulation of synaptic transmission and cellular organization. PSD95 Protein, Rat (His) is the recombinant rat-derived PSD95 protein, expressed by E. coli , with N-6*His labeled tag.
PSD95 Protein plays a crucial role in various functions, including PDZ domain binding, enzyme binding, and signaling receptor binding. It serves as a structural component of the postsynaptic density and is involved in processes such as modulation of chemical synaptic transmission, positive regulation of cellular component organization, and postsynapse organization. It is located in different cellular components, including the dendrite, juxtaparanode region of the axon, and postsynaptic density. PSD95 Protein is active in glutamatergic synapses and serves as an anchored component of the postsynaptic density membrane. It colocalizes with the postsynaptic membrane and is identified as a biomarker in Parkinson's disease and temporal lobe epilepsy. In humans, mutations in the orthologous DLG4 gene have been linked to autosomal dominant non-syndromic intellectual disability. [provided by Alliance of Genome Resources, Apr 2022] PSD95 Protein exhibits biased expression in the brain (RPKM 195.0), adrenal gland (RPKM 29.1), and seven other tissues.
Technical Parameters
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Species Rat
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Source E. coli
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Tag N-6*His
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Accession
NP_062567 (M1-L724)
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Molecular Construction
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N-term
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6*His
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PSD95 (M1-L724)
Accession # NP_062567 -
C-term
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Protein Length
Full Length
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Synonyms
DLG4; Postsynaptic Density Protein 95; Discs Large MAGUK Scaffold Protein 4; Tax Interaction Protein 15; SAP-90; Discs Large Homolog 4; PSD95; Discs, Large Homolog 4 (Drosophila), Isoform CRA_d; SAP90; Discs, Large Homolog 4 (Drosophila); Synapse-Associat
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AA Sequence
MDCLCIVTTKKYRYQDEDTPPLEHSPAHLPNQANSPPVIVNTDTLEAPGYELQVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKDCGFLSQALSFRFGDVLHVIDAGDEEWWQARRVHSDSETDDIGFIPSKRRVERREWSRLKAKDWGSSSGSQGREDSVLSYETVTQMEVHYARPIIILGPTKDRANDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKRITEEQARKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVPARERL
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Predicted Molecular Mass
81.9 kDa
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Molecular Weight
Approximately 110 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 80%, as determined by reducing SDS-PAGE.
Documentation
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Data Sheet (240 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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