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TAMALIN - Tamalin trafficking regulator and scaffold protein tamalin Gene

Also Known as Grasp

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 192254

Summary

Enables PDZ domain binding activity; identical protein binding activity; and small GTPase binding activity. Involved in protein localization. Located in plasma membrane. Is active in glutamatergic synapse and postsynaptic density. Orthologous to human TAMALIN (trafficking regulator and scaffold protein tamalin). [provided by Alliance of Genome Resources, Apr 2022]

TAMALIN Products (1)

mRNA	Protein	Name
NM_138894.1	NP_620249.1	general receptor for phosphoinositides 1-associated scaffold protein

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables PDZ domain binding	IDA IDA: Inferred from direct assay	11850456	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	12586822	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	12586822	RGD
enables small GTPase binding	IDA IDA: Inferred from direct assay	11850456	RGD

Cellular Component GO Annotation	Evidence	References	Source
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	11850456	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	11850456	RGD
is active in postsynaptic density	IDA IDA: Inferred from direct assay	11850456	RGD
is active in postsynaptic density	IMP IMP: Inferred from mutant phenotype	11850456	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
general receptor for phosphoinositides 1-associated scaffold protein	95 kDa postsynaptic density protein discs-large ZO-1 domain-containing protein GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein GRP1-associated scaffold protein Grp1 (general receptor for phosphoinositides)-associated scaffol

TAMALIN Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Tamalin	Q8R4T5	Grm5	Rattus norvegicus	P31424	X-Ray Diffraction	17396155
Intra	Tamalin	Q8R4T5	Grm5	Rattus norvegicus	P31424	Y2H	17396155
Intra	Tamalin	Q8R4T5	Dlg4	Rattus norvegicus	P31016	Anti Bait CoIP	12586822
Intra	Tamalin	Q8R4T5	Dlgap3	Rattus norvegicus	P97838	Y2H	12586822
Intra	Tamalin	Q8R4T5	Magi2	Rattus norvegicus	O88382	Anti Tag CoIP	17396155
Intra	Tamalin	Q8R4T5	Magi2	Rattus norvegicus	O88382	Anti Bait CoIP	12586822
Intra	Tamalin	Q8R4T5	Tamalin	Rattus norvegicus	Q8R4T5	X-Ray Diffraction	17396155
Intra	Tamalin	Q8R4T5	Tamalin	Rattus norvegicus	Q8R4T5	Pull Down	12586822
Intra	Tamalin	Q8R4T5	Tamalin	Rattus norvegicus	Q8R4T5	Y2H	17396155
Intra	Tamalin	Q8R4T5	Dlgap1	Rattus norvegicus	P97836	Anti Bait CoIP	12586822

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14192	TAMALIN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	TAMALIN	NCBI	NCBI:160622