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Magi2 - membrane associated guanylate kinase, WW and PDZ domain containing 2 Gene

Also Known as AIP-1; S-SCAM; Acvrip1; Acvrinp1

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 113970

Summary

Enables Kinesin binding activity. A structural constituent of postsynaptic density. Involved in several processes, including nerve growth factor signaling pathway; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane; and regulation of synaptic membrane adhesion. Located in several cellular components, including late endosome; perinuclear region of cytoplasm; and slit diaphragm. Part of protein-containing complex. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynaptic density. Is extrinsic component of postsynaptic membrane. Human ortholog(s) of this gene implicated in nephrotic syndrome type 15. Orthologous to human MAGI2 (membrane associated guanylate kinase, WW and PDZ domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]

Magi2 Products (1)

mRNA	Protein	Name
NM_053621.2	NP_446073.2	membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables kinesin binding	IPI IPI: Inferred from physical interaction	12097473	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	9694864	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	10644767	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	15331416	RGD
enables structural constituent of postsynaptic density	IDA IDA: Inferred from direct assay	22593065	RGD
enables structural constituent of postsynaptic density	IMP IMP: Inferred from mutant phenotype	22593065	RGD
enables structural constituent of postsynaptic specialization	IDA IDA: Inferred from direct assay	23751499	RGD
enables structural constituent of postsynaptic specialization	IMP IMP: Inferred from mutant phenotype	23751499	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to nerve growth factor stimulus	IDA IDA: Inferred from direct assay	17724123	RGD
involved in negative regulation of cell migration	IDA IDA: Inferred from direct assay	17880912	RGD
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	17880912	RGD
involved in nerve growth factor signaling pathway	IDA IDA: Inferred from direct assay	17724123	RGD
involved in podocyte development	IEP IEP: Inferred from expression pattern	15994232	RGD
involved in positive regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	17724123	RGD
involved in receptor clustering	IDA IDA: Inferred from direct assay	10644767	RGD
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IDA IDA: Inferred from direct assay	22593065	RGD
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IMP IMP: Inferred from mutant phenotype	22593065	RGD
involved in regulation of synaptic membrane adhesion	IDA IDA: Inferred from direct assay	23751499	RGD
involved in regulation of synaptic membrane adhesion	IMP IMP: Inferred from mutant phenotype	23751499	RGD

Cellular Component GO Annotation	Evidence	References	Source
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	17059560	RGD
is active in GABA-ergic synapse	IMP IMP: Inferred from mutant phenotype	23751499	RGD
located in cytoplasm	IDA IDA: Inferred from direct assay	17724123	RGD
located in dendrite	IDA IDA: Inferred from direct assay	10548487	RGD
is active in extrinsic component of postsynaptic membrane	IDA IDA: Inferred from direct assay	17059560	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	9694864	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	22593065	RGD
located in late endosome	IDA IDA: Inferred from direct assay	17724123	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	12589829	RGD
is active in postsynaptic density	IDA IDA: Inferred from direct assay	9694864	RGD
located in postsynaptic density	IDA IDA: Inferred from direct assay	12589829	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	15331416	RGD
located in slit diaphragm	IDA IDA: Inferred from direct assay	15994232	RGD
located in synapse	IDA IDA: Inferred from direct assay	10548487	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2	activin receptor interacting protein 1 atrophin-1-interacting protein 1 membrane-associated guanylate kinase inverted 2 synaptic-scaffolding molecule

Magi2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	Magi2	O88382	CRHR1	Homo sapiens	P34998	Anti Tag CoIP	26352593
Cross	Magi2	O88382	DDN	Homo sapiens	O94850	Pull Down	16751601
Cross	Magi2	O88382	PTEN	Homo sapiens	P60484	Anti Tag CoIP	15951562
Cross	Magi2	O88382	PTEN	Homo sapiens	P60484	Pull Down	15951562
Intra	Magi2	O88382	Tamalin	Rattus norvegicus	Q8R4T5	Anti Bait CoIP	12586822
Intra	Magi2	O88382	Tamalin	Rattus norvegicus	Q8R4T5	Pull Down	12586822
Intra	Magi2	O88382	Dlgap1	Rattus norvegicus	P97836	Y2H	9694864
Intra	Magi2	O88382	Dlgap1	Rattus norvegicus	P97836	Filter Binding	9694864

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07982	MAGI2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22622	Magi2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Magi2	NCBI	NCBI:9863