Vangl1 - VANGL planar cell polarity 1 Gene

Also Known as Lpp2; Stb2; Stbm; Kitenin

Species: Mus musculus

Gene Type: protein coding
Gene ID: 229658

Summary

Acts upstream of or within pigmentation. Located in lateral plasma membrane. Is expressed in several structures, including central nervous system; cochlea; future brain; notochord; and skin. Used to study neural tube defect. Human ortholog(s) of this gene implicated in caudal regression syndrome and neural tube defect. Orthologous to human VANGL1 (VANGL planar cell polarity protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Vangl1 Products (1)

mRNA Protein Name
NM_177545.5 NP_808213.2 vang-like protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15456783 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within mucociliary clearance IMP
IMP: Inferred from mutant phenotype
33929515 MGI
acts upstream of or within pigmentation IMP
IMP: Inferred from mutant phenotype
25340873 MGI
Cellular Component GO Annotation Evidence References Source
located in lateral plasma membrane IDA
IDA: Inferred from direct assay
22935613 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

vang-like protein 1

  • KAI1 COOH-terminal interacting tetraspanin

  • loop-tail protein 2

  • strabismus

  • van Gogh-like protein 1

  • vang, van gogh-like 1

  • vang-like 1 (van gogh, Drosophila)

Vangl1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Vangl1 Q80Z96 Dvl1 Mus musculus P51141
Y2H
15456783
Intra
Vangl1 Q80Z96 Dvl3 Mus musculus Q61062
Pull Down
15456783
Intra
Vangl1 Q80Z96 Dvl2 Mus musculus Q60838
Pull Down
15456783
Intra
Vangl1 Q80Z96 Dvl2 Mus musculus Q60838
Anti Bait CoIP
15456783
Intra
Vangl1 Q80Z96 Dvl2 Mus musculus Q60838
Y2H
15456783
Cross
Vangl1 Q80Z96 Dlg4 Rattus norvegicus P31016
Pull Down
23567299
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15600 VANGL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Vangl1 NCBI NCBI:81839